Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm
Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm
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DOI：
10.1007/978-981-10-5526-3_8
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Osumi, Noriko
中科院分区：
文献类型：
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作者：
Kimura, Ryuichi;Yoshizaki, Kaichi;Osumi, Noriko
自从 DOHaD 理论成为人们关注的焦点以来，大多数注意力都集中在子宫环境对发育中的胚胎/胎儿的影响上。然而，个体发生可以追溯到配子发生。与卵子发生相比，精子发生经历更多的细胞分裂，因此更容易发生遗传变异和表观遗传改变。本文将主要讨论关于父亲高龄对下一代的影响的最新发现，这与自闭症谱系障碍等精神疾病的发病有关。我们主张在更广阔的视野中对DOHaD理论进行进一步的探索。
Sincethe theory of DOHaD has been thrown in the spotlight, most attention has focused on environmental effects of the uterus on developing embryos/fetuses. However, the ontogenesis traces back to gametogenesis. Compared to oogenesis, spermatogenesis goes through far more cell divisions and is therefore more prone to genetic variation and epigenetic alterations. This article will mainly discuss recent findings about the effects of the advanced paternal age on the next generation, in relation to the onset of psychiatric disorders such as autism spectrum disorder. We would like to advocate for further exploration on the DOHaD theory in a wider view.