The neural mechanisms of social reward in early psychosis
The neural mechanisms of social reward in early psychosis
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DOI：
10.1093/scan/nsz058
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发表时间：
2019-08-01
影响因子：
4.2
通讯作者：
Krabbendam, Lydia
中科院分区：
文献类型：
--
作者：
Fett, Anne-Kathrin J.;Mouchlianitis, Elias;Krabbendam, Lydia
在慢性精神病中，信任减少与神经对社会奖励不敏感和心理理论（ToM）降低有关。在这里，我们调查这些机制是否可能成为早期精神病中出现的社会障碍的基础。22名早期精神病患者和25名对照组（男性，13-19岁）参加了两个互动的信任游戏，对合作和不公平的合作伙伴。感兴趣区域的神经影像学分析包括右尾状核，内侧前额叶皮质（mPFC）和右颞顶交界处（rTPJ），参与奖励和心理理论的处理。两组人表现出相似的信任程度（即投资）。然而，患有精神病的个体在做出信任决定时，未能激活尾状核以应对合作和不公平。在合作回报，患者表现出减少和控制增加尾状核激活。患者表现出更大的rTPJ激活比对照组，可能指向代偿机制。影响与韦氏简明智力量表词汇评分相关。mPFC激活无组间差异。早期精神病与对社会奖励的异常神经敏感性有关。这可能导致社会积极性降低和社会孤立。缺乏早期的行为差异，相对于慢性精神病可能表明，信任是通过增加对心理理论的补偿性需求来实现的。
In chronic psychosis, reduced trust is associated with a neural insensitivity to social reward and reduced theory of mind (ToM). Here we investigate whether these mechanisms could underlie emerging social impairments in early psychosis. Twenty-two participants with early psychosis and 25 controls (male, 13-19 years) participated in two interactive trust games against a cooperative and unfair partner. Region of interest neuroimaging analyses included right caudate, medial prefrontal cortex (mPFC) and right temporoparietal junction (rTPJ), involved in reward and ToM processing. Both groups showed similar levels of trust (i.e. investments). However, individuals with psychosis failed to activate the caudate differentially in response to cooperation and unfairness while making decisions to trust. During cooperative returns, patients showed reduced and controls increased caudate activation. Patients demonstrated greater rTPJ activation than controls, possibly pointing towards compensatory mechanisms. Effects were associated with Wechsler Abbreviated Scale of Intelligence vocabulary scores. No group differences emerged in mPFC activation. Early psychosis is associated with an aberrant neural sensitivity to social reward. This could foster reduced social motivation and social isolation. Absent behavioural differences in early, relative to chronic psychosis could indicate that trust is achieved through increased compensatory demand on ToM.