Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report
Antidepressive effect of left dorsolateral prefrontal cortex neurofeedback in patients with major depressive disorder: A preliminary report
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DOI：
10.1016/j.jad.2020.03.080
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发表时间：
2020-06-15
影响因子：
6.6
通讯作者：
Yamawaki, Shigeto
中科院分区：
文献类型：
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作者：
Takamura, Masahiro;Okamoto, Yasumasa;Yamawaki, Shigeto
背景实时功能磁共振神经反馈(rtfMRI-nf)作为一种治疗重度抑郁障碍(MDD)的新的个体化治疗方法，近年来引起了人们的关注。本研究旨在观察神经反馈训练对左侧背外侧前额叶皮质(DLPFC)活动的抗抑郁作用。在每一次治疗中，患者观察到他们左侧DLPFC内的一个粗体信号作为折线图，并试图使用图形提示上调信号。结果经过神经反馈训练后，患者的临床症状明显改善。此外，患者对神经反馈训练的熟练程度与反省症状的改善显著相关。限制研究的局限性包括缺乏对照组或条件，缺乏转移跑，以及参与者人数较少。结论本小样本研究提示DLPFC活动调节训练对MDD的治疗可能有效。下一步，需要一项假对照随机临床试验来证实左DLPFC神经反馈的抗抑郁效果。
Background Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) have recently attracted attention as a novel, individualized treatment method for major depressive disorder (MDD). In this study, the antidepressant effect of neurofeedback training for left dorsolateral prefrontal cortex (DLPFC) activity was examined.Methods Six patients with MDD completed 5 days of neurofeedback training sessions. In each session, the patients observed a BOLD signal within their left DLPFC as a line graph, and attempted to up-regulate the signal using the graphical cue. Primary outcome measures were clinical scales of severity of depression and rumination.Results After neurofeedback training, the clinical measures were improved significantly. In addition, patient proficiency for neurofeedback training was related significantly to the improvement of the rumination symptom.Limitations Study limitations include the lack of a control group or condition, the lack of transfer run, and the small number of participants.Conclusions This small sample study suggests the possible efficacy of DLPFC activity regulation training for the treatment of MDD. As a next step, a sham-controlled randomized clinical trial is needed to confirm the antidepressive effect of left DLPFC neurofeedback.