Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task
Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task
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DOI：
10.1037/0735-7044.111.1.104
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发表时间：
1997-02-01
影响因子：
1.9
通讯作者：
Wehner, JM
中科院分区：
文献类型：
--
作者：
Logue, SE;Paylor, R;Wehner, JM
本研究探讨了海马损伤对近交系小鼠Morris水迷宫和条件性恐惧任务获得的影响。对C57 BL/6 J、DBA/2 J和B6 D2 F1杂交小鼠进行海马损伤或假手术，然后进行测试。相对于假手术对照组，损伤的C57 BL/6 J和B6 D2 F1小鼠未能学习Morris任务，DBA组也没有学习该任务。在条件性恐惧的上下文组件中，病变减少了所有菌株的冻结。但这种损伤仅影响DBA/2 J和B6 D2 F1品系对条件刺激的冻结。这些数据表明，C57 BL/6 J和B6 D2 F1小鼠使用海马来解决Morris水迷宫和条件恐惧任务，DBA小鼠在一定程度上使用海马来解决条件恐惧任务。
This study examined the effect of hippocampal lesions on acquisition of the Morris water maze and conditioned-fear task in inbred mice. C57BL/6J, DBA/2J, and B6D2F1 hybrid mice were given hippocampal lesions or sham surgery and then tested. The lesioned C57BL/6J and B6D2F1 mice failed to learn the Morris task relative to sham-operated controls, and no DBA group learned the task. In the contextual component of conditioned fear, lesions decreased freezing in all strains. But the lesions only affected freezing to the conditioned stimulus in the DBA/2J and B6D2F1 strains. These data demonstrate that C57BL/6J and B6D2F1 mice use the hippocampus to solve the Morris water maze and conditioned-fear task, and the DBA mice use the hippocampus, to some degree, in the conditioned-fear task.