Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors?
Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors?
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因子 VIII 替代疗法的优化：结构研究能否帮助规避抗体抑制剂？
DOI：
10.1046/j.1365-2141.2002.03845.x
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发表时间：
2002
影响因子：
6.5
通讯作者：
Stoddard,BarryL
中科院分区：
文献类型：
--
作者：
SpiegelJr,PClint;Stoddard,BarryL
通过对因子VIII替代疗法的结构研究，对其规避抗体抑制剂进行优化研究。血友病A抗体抑制剂的治疗及研究进展因子VIII的结构域结构与功能因子VIII抑制因子表位及其失活机制将抑制剂表位定位到功能表面；向猪学习因子VIII。
Studies the optimization of factor VIII replacement therapy by its structural studies that could help in evading antibody inhibitors. Treatment and development of antibody inhibitors for hemophilia A; Domain structure and function of factor VIII; Factor VIII inhibitor epitopes and mechanisms of inactivation; Mapping inhibitor epitopes to functional surfaces; Learning from porcine factor VIII.