Feasibility and impact of a guided symptom exposure augmented cognitive behavior therapy protocol to prevent symptoms of pharmacologically induced depression: A pilot study.
Feasibility and impact of a guided symptom exposure augmented cognitive behavior therapy protocol to prevent symptoms of pharmacologically induced depression: A pilot study.
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引导症状暴露增强认知行为治疗方案预防药物诱发抑郁症状的可行性和影响：一项试点研究。
DOI：
10.1007/s10608-018-09990-7
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发表时间：
2019
影响因子：
2.8
通讯作者：
McGinn,ThomasG
中科院分区：
文献类型：
--
作者：
McGinn,LataK;VanMeter,Anna;Kronish,Ian;Gashin,Jessica;Burns,Karen;Kil,Natalie;McGinn,ThomasG
抑郁症是导致残疾的主要原因，也是全球发病率的主要原因，目前全球的社会成本高达1万亿美元。因此，扩大目前的努力以增强预防成果符合全球公共卫生利益。尽管已经开发了许多预防计划并证明了其有效性，但研究尚未证明CBT在预防由药理物质导致的抑郁症高危人群中的症状方面是有效的。使用随机对照设计，这项先导性研究报告了一种新的、引导症状暴露增强认知行为预防干预(GSE-CBT)的可行性和初步效果，该干预措施在一个被诊断为丙型肝炎有发生药物性抑郁风险的样本中进行。结果表明，引导性症状暴露增强CBT(GSE-CBT)在该人群中是可行的，并具有高度的完整性。尽管在统计学上没有差异，但我们始终观察到GSE-CBT组与对照组相比抑郁水平较低的模式。这项初步研究表明，心理社会预防干预对于有发生药物性抑郁症的风险的患者是可行的，并且引导症状暴露增强的CBT方案有可能预防抑郁症状，这些症状会发展为服用这些药物的副作用。结果是初步的，未来的研究应该使用更大的样本，并在其他人群中测试干预措施。
Depression is the leading cause of disability and a major cause of morbidity worldwide, with societal costs now upwards of 1 trillion dollars across the globe. Hence, extending current efforts to augment prevention outcomes is consistent with global public health interests. Although many prevention programs have been developed and have demonstrated efficacy, studies have yet to demonstrate that CBT is effective in preventing symptoms in populations at risk for developing depression induced by pharmacological substances. Using a randomized, controlled design, this pilot study reports on the feasibility and preliminary effects of a novel, guided symptom exposure augmented cognitive behavioral prevention intervention (GSE-CBT) in a sample diagnosed with Hepatitis C at risk for developing medication induced depression. Results demonstrated that the guided symptom exposure augmented CBT (GSE-CBT) was feasible in this population and was delivered with high integrity. Although not statistically different, we observed a pattern of lower depression levels in the GSE-CBT group versus those in the control group throughout. This pilot study demonstrates that a psychosocial prevention intervention is feasible for use in patients at risk for developing pharmacologically induced depression and that a guided symptom exposure augmented CBT protocol has the potential to prevent symptoms of depression that develop as a side effect to taking these medications. Results are preliminary and future studies should use larger samples and test the intervention in other populations.