GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update
GenomeRNAi: a database for cell-based RNAi phenotypes. 2009 update
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DOI：
10.1093/nar/gkp1038
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发表时间：
2010-01-01
影响因子：
14.9
通讯作者：
Boutros, Michael
中科院分区：
文献类型：
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作者：
Gilsdorf, Moritz;Horn, Thomas;Boutros, Michael
GenomeRNAi数据库（http://www.genomernai.org/）包含已发表的果蝇和智人基于细胞的RNA干扰（RNAi）筛选的表型。该数据库将观察到的表型与目标基因的注释和用于扰动实验的RNAi试剂的信息联系起来。来自果蝇和人类屏幕的表型的可用性也允许跨物种的表型搜索。除了报告基因组尺度筛选的定量数据外，GenomeRNAi的新版本还可以报告来自显微镜实验的数据和来自已发表筛选的精心整理的表型。此外，该数据库还提供了可用于果蝇和人类基因组的RNAi试剂及其预测质量的更新资源。新版本还促进了与其他基因组数据集的整合，并包含RNAi实验中常用的几种细胞系的表达谱（RNA-Seq）数据。
The GenomeRNAi database (http://www.genomernai.org/) contains phenotypes from published cell-based RNA interference (RNAi) screens in Drosophila and Homo sapiens. The database connects observed phenotypes with annotations of targeted genes and information about the RNAi reagent used for the perturbation experiment. The availability of phenotypes from Drosophila and human screens also allows for phenotype searches across species. Besides reporting quantitative data from genome-scale screens, the new release of GenomeRNAi also enables reporting of data from microscopy experiments and curated phenotypes from published screens. In addition, the database provides an updated resource of RNAi reagents and their predicted quality that are available for the Drosophila and the human genome. The new version also facilitates the integration with other genomic data sets and contains expression profiling (RNA-Seq) data for several cell lines commonly used in RNAi experiments.