Actin up: shifting chromosomes toward repair, but also translocations.
Actin up: shifting chromosomes toward repair, but also translocations.
复制标题
肌动蛋白上行：染色体向修复方向移动，但也发生易位。
DOI：
10.1038/s41594-022-00906-4
复制
发表时间：
2023
影响因子：
16.8
通讯作者：
McCord,RachelPatton
中科院分区：
文献类型：
--
作者：
Li,Heng;McCord,RachelPatton
核肌动蛋白聚合有助于促进染色体区室转换，从而将受损的 DNA 转移到有利于 DNA 修复的核环境中。然而，将多条断裂的 DNA 链转移到一起也会增加 DNA 末端错误连接以及随后形成易位的可能性。
Nuclear actin polymerization helps facilitate chromosome compartment switches that can shift damaged DNA toward a nuclear environment that is favorable for DNA repair. Yet shifting multiple broken DNA strands together can also increase the likelihood of misjoining of the DNA ends and subsequent formation of translocations.