Silver-catalyzed 2-isocyanobiaryls insertion/cyclization with phosphine oxides: synthesis of 6-phosphorylated phenanthridines
Silver-catalyzed 2-isocyanobiaryls insertion/cyclization with phosphine oxides: synthesis of 6-phosphorylated phenanthridines
复制标题
银催化 2-异氰基联苯插入/氧化膦环化：6-磷酸化菲啶的合成
DOI：
10.1016/j.tet.2014.07.078
复制
发表时间：
2014-09-30
期刊：
影响因子：
2.1
通讯作者：
Ji, Shun-Jun
中科院分区：
文献类型：
--
作者：
Cao, Jia-Jia;Zhu, Tong-Hao;Ji, Shun-Jun
在银催化下，2-异氰基联苯与氧化膦发生插入/环化反应，通过原位生成的P-中心自由基与2-异氰基联苯的自由基加成和均裂芳香取代反应，合成了6-磷酸化菲啶.在20mol%的AgOAc和3.0equiv的PhI（OAc）（2）的催化下，反应可以顺利进行，得到所需的6-磷酸化菲啶。(C)2014爱思唯尔有限公司版权所有。
A silver-catalyzed 2-isocyanobiaryls insertion/cyclization with phosphine oxides was described for the construction of the 6-phosphorylated phenanthridines through radical addition of in situ formed P-centered radical to 2-isocyanobiphenyls and homolytic aromatic substitution process. The reactions could proceed smoothly to give the desired 6-phosphorylated phenanthridines promoted by AgOAc (20 mol %) with PhI(OAc)(2) (3.0 equiv). (C) 2014 Elsevier Ltd. All rights reserved.