Activation likelihood estimation meta-analysis of brain correlates of placebo analgesia in human experimental pain
Activation likelihood estimation meta-analysis of brain correlates of placebo analgesia in human experimental pain
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DOI：
10.1002/hbm.21471
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发表时间：
2013-03-01
影响因子：
4.8
通讯作者：
Cauda, Franco
中科院分区：
文献类型：
--
作者：
Amanzio, Martina;Benedetti, Fabrizio;Cauda, Franco
安慰剂镇痛（PA）是研究最多的安慰剂效应之一。在过去十年中发表的脑成像研究，使用正电子发射断层扫描（PET）或功能性磁共振成像（fMRI），表明多个大脑区域可能在这一过程中发挥关键作用。然而，对于哪些区域始终对安慰剂相关网络做出贡献，仍然存在很多争论。在本研究中，我们使用激活似然估计（ALE）的荟萃分析，一个国家的最先进的方法，在人类实验性疼痛模型中寻找参与PA的皮质区。研究脑血流动力学变化的9项fMRI研究和2项PET研究被纳入分析。在预期镇痛期间，在左侧前扣带回、右侧中央前区和外侧前额叶皮质以及左侧导水管周围灰质（PAG）中发现了激活灶。在伤害性刺激期间，在扣带回前部、内侧和外侧前额叶皮质、左侧顶下小叶和中央后回、前额叶、丘脑、下丘脑、PAG和脑桥中检测到安慰剂相关激活;在左侧中后扣带回皮质、上级颞回和中央前回、左前和右后回、屏状核和壳核，右侧丘脑和尾状体也有我们的研究结果表明，一方面，参与PA的调节皮层网络在很大程度上重叠的情绪过程的调节，另一方面，大脑伤害性网络下调与行为镇痛。^Brain Mapp，2013. (c)2011 Wiley Periodicals，Inc.
Placebo analgesia (PA) is one of the most studied placebo effects. Brain imaging studies published over the last decade, using either positron emission tomography (PET) or functional magnetic resonance imaging (fMRI), suggest that multiple brain regions may play a pivotal role in this process. However, there continues to be much debate as to which areas consistently contribute to placebo analgesia-related networks. In the present study, we used activation likelihood estimation (ALE) meta-analysis, a state-of-the-art approach, to search for the cortical areas involved in PA in human experimental pain models. Nine fMRI studies and two PET studies investigating cerebral hemodynamic changes were included in the analysis. During expectation of analgesia, activated foci were found in the left anterior cingulate, right precentral, and lateral prefrontal cortex and in the left periaqueductal gray (PAG). During noxious stimulation, placebo-related activations were detected in the anterior cingulate and medial and lateral prefrontal cortices, in the left inferior parietal lobule and postcentral gyrus, anterior insula, thalamus, hypothalamus, PAG, and pons; deactivations were found in the left mid- and posterior cingulate cortex, superior temporal and precentral gyri, in the left anterior and right posterior insula, in the claustrum and putamen, and in the right thalamus and caudate body. Our results suggest on one hand that the modulatory cortical networks involved in PA largely overlap those involved in the regulation of emotional processes, on the other that brain nociceptive networks are downregulated in parallel with behavioral analgesia. Hum Brain Mapp, 2013. (c) 2011 Wiley Periodicals, Inc.