Effectiveness of botulinum toxin administered to abolish acquired nystagmus.
Effectiveness of botulinum toxin administered to abolish acquired nystagmus.
复制标题
施用肉毒杆菌毒素消除获得性眼球震颤的有效性。
DOI：
10.1002/ana.410320506
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发表时间：
1992
影响因子：
11.2
通讯作者：
Dell'Osso,LF
中科院分区：
文献类型：
--
作者：
Leigh,RJ;Tomsak,RL;Grant,MP;Remler,BF;Yaniglos,SS;Lystad,L;Dell'Osso,LF
我们将肉毒杆菌毒素注射到 2 名患有水平、垂直和扭转成分的摆动性眼球震颤患者的右眼水平直肌中。这种治疗成功地消除了两名患者注射眼中眼球震颤的水平分量，持续约两个月。两名患者的注射眼视力均出现小幅但可测量的改善，这可能受到视觉通路共存疾病的限制。两名患者的眼球震颤的垂直和扭转成分均持续存在。 1 名患者未注射眼的眼球震颤水平分量增加；我们将这一发现归因于针对肉毒杆菌毒素引起的麻痹的塑料适应性变化。这种塑料适应性变化和注射的直接副作用（例如复视和上睑下垂）可能会限制肉毒杆菌毒素治疗获得性眼球震颤的有效性。两名患者都没有选择重复肉毒杆菌治疗。
We injected botulinum toxin into the horizontal rectus muscles of the right eyes of 2 patients who had acquired pendular nystagmus with horizontal, vertical, and torsional components. This treatment successfully abolished the horizontal component of the nystagmus in the injected eye in both patients for approximately 2 months. Both patients showed a small but measurable improvement of vision in the injected eye that may have been limited by coexistent disease of the visual pathways. The vertical and torsional components of the nystagmus persisted in both patients. In 1 patient, the horizontal component of nystagmus in the noninjected eye increased; we ascribe this finding to plastic‐adaptive changes in response to paresis caused by the botulinum toxin. Such plastic‐adaptive changes and direct side effects of the injections—such as diplopia and ptosis—may limit the effectiveness of botulinum toxin in the treatment of acquired nystagmus. Neither patient elected to repeat the botulinum treatment.