Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine.
Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine.
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巯基和甲状腺素单脱碘为三碘甲状腺原氨酸。
DOI：
10.1126/science.622575
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发表时间：
1978
期刊：
影响因子：
56.9
通讯作者：
I. Chopra
中科院分区：
文献类型：
--
作者：
I. Chopra
在体外实验中，巯基试剂对大鼠和绵羊组织中甲状腺素单脱碘为三碘甲腺原氨酸的反应有深远的影响。二硫苏糖醇诱导的胎羊肝匀浆的单脱碘显著增加，这表明胎儿组织的低转化率更多地与巯基的状态有关，而不是与单脱碘酶的缺乏有关。
Sulfhydryl reagents exert a profound influence on the monodeiodination of thyroxine to triiodothyronine by rat and sheep tissues in vitro. A marked dithiothreitol-induced increase in the monodeiodination by fetal sheep liver homogenates suggests that the characteristically low conversion in fetal tissues is related more to the status of sulfhydryl groups than to a deficiency of the monodeiodinating enzyme.