Rhodium(I)-CatalyzedHydroacylation/Cycloisomerization Cascade Reaction: Applicationto the Construction of the Tricyclic Core of Guanacastepenes
Rhodium(I)-CatalyzedHydroacylation/Cycloisomerization Cascade Reaction: Applicationto the Construction of the Tricyclic Core of Guanacastepenes
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DOI：
10.1055/s-0030-1258184
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发表时间：
2010-09
期刊：
影响因子：
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通讯作者：
Yoshihiro Oonishi;Ai Taniuchi;Y. Sato
中科院分区：
文献类型：
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作者：
Yoshihiro Oonishi;Ai Taniuchi;Y. Sato
我们以前开发了一种新的铑（I）催化的级联反应，涉及加氢酰化的4，6-二烯醛，然后环异构化所得的1，3-二烯与烯烃，得到含有双环[5.3.0]癸烯酮骨架的碳环在立体选择性的方式。在此，我们报告的建设的C5，C7，C6三环核心的guanacastepene使用这种级联反应。
We previously developed a novel rhodium(I)-catalyzed cascade reaction involving the hydroacylation of a 4,6-dienal followed by cycloisomerization of the resulting 1,3-diene with an alkene, giving carbocycles containing a bicyclo[5.3.0]decenone skeleton in a stereoselective manner. Herein, we report the construction of the C 5 ,C 7 ,C 6 -tricyclic core of guanacastepenes using this cascade reaction.