Review on Trypanosoma cruzi: Host Cell Interaction.
Review on Trypanosoma cruzi: Host Cell Interaction.
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DOI：
10.1155/2010/295394
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Barrias, Emile Santos
中科院分区：
文献类型：
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作者：
de Souza, Wanderley;de Carvalho, Tecia Maria Ulisses;Barrias, Emile Santos
克氏锥虫是恰加斯病的病原体，影响中美洲和南美洲的大量个体，它通过吸血昆虫传播给脊椎动物宿主。这种原生动物是专性细胞内寄生虫。寄生虫的感染形式是超循环和血流锥马鞭毛虫和无马鞭毛虫。超循环锥马鞭毛虫随昆虫的粪便释放，而无尾鞭毛虫和血流锥马鞭毛虫则在经过复杂的细胞内生命周期后从脊椎动物宿主的感染宿主细胞释放。寄生虫和哺乳动物宿主细胞之间的识别涉及两种细胞类型中存在的许多分子。本文就克氏锥虫与宿主细胞的相互作用作一综述，重点阐述了克氏锥虫侵染宿主细胞的机制和分子。
Trypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyclic and bloodstream trypomastigote and amastigote. Metacyclic trypomastigotes are released with the feces of the insect while amastigotes and bloodstream trypomastigotes are released from the infected host cells of the vertebrate host after a complex intracellular life cycle. The recognition between parasite and mammalian host cell involves numerous molecules present in both cell types. Here, we present a brief review of the interaction between Trypanosoma cruzi and its host cells, mainly emphasizing the mechanisms and molecules that participate in the T. cruzi invasion process of the mammalian cells.