DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease.
DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease.
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DOI：
10.1186/1546-0096-11-32
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发表时间：
2013-09-05
期刊：
影响因子：
--
通讯作者：
Shrestha S
中科院分区：
文献类型：
--
作者：
Portman MA;Wiener HW;Silva M;Shendre A;Shrestha S
抑制FcγRIIB的遗传变异介导抗炎反应并影响IVIG难治性（IVIG- r）。然而，这些变异在亚洲和西班牙裔人群中很少见，因此该途径中的其他基因可能参与其中。IVIG在缺乏与人类DC-SIGN相关的分子SIGN-R1的小鼠中无效。此外，DC-SIGN是唾液化Fc的已知受体，该成分负责IVIG的抗炎作用。因此，我们假设DC-SIGN也可能参与川崎病（KD）患者IVIG应答通路。采用病例对照方法，研究了白人（158人对62人）、亚洲人（64人对12人）和西班牙人（55人对20人）KD患者中带有IVIG-R的DC-SIGN启动子中5个单核苷酸多态性（snp）的差异分布。在三个民族中，DC-SIGN启动子中几个变异的等位基因频率分布存在明显差异。此外，具有rs2287886主要等位基因“A”的亚洲人更有可能成为IVIG无应答者（OR = 1.76, p = 0.04），但该等位基因在其他两个种族中是一个次要等位基因，其相关性不明显。DC-SIGN可能在参与IVIG反应机制的抗炎级联中补充fc - γ riib的作用。
Genetic variants in the inhibiting FcγRIIB mediate anti-inflammatory responses and influence IVIG refractoriness (IVIG-R). However, these variants are rare in Asian and Hispanic populations so other genes in the pathway could be potentially involved. IVIG is ineffective in mice lacking SIGN-R1, a related molecule to human DC-SIGN. Further, DC-SIGN is a known receptor for sialylated Fc, the component responsible for the anti-inflammatory action of IVIG. Thus, we hypothesized that DC-SIGN would also be involved in the pathway of IVIG response in Kawasaki Disease (KD) patients. A case-control approach was performed to examine the differential distribution of five single nucleotide polymorphisms (SNPs) in DC-SIGN promoter with IVIG-R among White (158 vs. 62), Asian (64 vs. 12) and Hispanic (55 vs. 20) KD patients. Distinct differences in allele frequency distributions of several variants in the DC-SIGN promoter were observed in the three ethnic groups. Further, Asians with the major allele “A” in rs2287886 were more likely (OR = 1.76, p = 0.04) to be IVIG non-responder, but this allele is a minor allele in other two ethnic groups, where the association was not apparent. DC-SIGN can potentially complement the role of FcγRIIB in the anti-inflammatory cascade involved in the IVIG response mechanism.
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影响因子：
3.6
作者：
Holman, Robert C.;Belay, Ermias D.;Schonberger, Lawrence B.
通讯作者：
Schonberger, Lawrence B.
影响因子：
3.6
作者：
Burns, JC;Capparelli, EV;Glode, MP
通讯作者：
Glode, MP
DOI：
10.1073/pnas.0810163105
发表时间：
2008-12-16
影响因子：
11.1
作者：
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通讯作者：
Ravetch, Jeffrey V.
影响因子：
5.4
作者：
Martin, MP;Lederman, MM;Carrington, M
通讯作者：
Carrington, M
影响因子：
8.8
作者：
Chaudhary, Omkar;Rajsekar, Kavitha;Luthra, Kalpana
通讯作者：
Luthra, Kalpana