Relationship Between the Loudness Dependence of the Auditory Evoked Potential and the Severity of Suicidal Ideation in Patients with Major Depressive Disorder.
Relationship Between the Loudness Dependence of the Auditory Evoked Potential and the Severity of Suicidal Ideation in Patients with Major Depressive Disorder.
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DOI：
10.9758/cpn.2021.19.2.323
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发表时间：
2021-05-31
期刊：
影响因子：
--
通讯作者：
Hahn SW
中科院分区：
文献类型：
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作者：
Hwang M;Lee YJ;Lee M;Kang B;Lee YS;Hwang J;Woo SI;Hahn SW
听觉诱发电位（LDAEP）的响度依赖性是一个可靠的指标，与中枢神经系统的活动呈负相关，最近的研究表明LDAEP和自杀意念之间的关联。本研究调查了与健康对照相比，重度抑郁症和高自杀倾向患者与重度抑郁症和低自杀倾向患者之间LDAEP的差异。本研究包括67名参与者，其中23名为具有高度自杀倾向的重性抑郁症患者，（9例男性，平均年龄29.3 ± 15.7岁，SSI-BECK总分≥ 15），22例重度抑郁症患者，自杀倾向较低（9名男性，平均年龄42.2 ± 14.4岁，SSI-BECK总分≤ 14）和22名健康对照（11名男性，平均年龄31.6 ± 8.7岁）。参与者完成了以下评估：患者健康问卷-9、Beck抑郁量表-II、Beck自杀意念量表、状态-特质焦虑量表的状态焦虑量表、Beck焦虑量表和LDAEP（在电极Cz处测量）。组间无性别相关差异（p = 0.821）。高自杀倾向组的LDAEP显著高于低自杀倾向组（0.82 ± 0.79 vs. 0.26 ± 0.36，p = 0.014）。对照组和高自杀倾向组（p = 0.281）或对照组和低自杀倾向组（p = 0.236）之间无显著差异。LDAEP可作为抑郁症预防自杀的生物学标志物。
The loudness dependence of the auditory evoked potential (LDAEP) is a reliable indicator that is inversely related to central serotonergic activity, and recent studies have suggested an association between LDAEP and suicidal ideation. This study investigated differences in LDAEP between patients with major depressive disorder and high suicidality and those with major depressive disorder and low suicidality compared to healthy controls. This study included 67 participants 23 patients with major depressive disorder with high suicidality (9 males, mean age 29.3 ± 15.7 years, total score of SSI-BECK ≥ 15), 22 patients with major depressive disorder with low suicidality (9 males, mean age 42.2 ± 14.4 years, total score of SSI-BECK ≤ 14), and 22 healthy controls (11 males, mean age 31.6 ± 8.7 years). Participants completed the following assessments Patient Health Questionnaire-9, Beck Depression Inventory-II, Beck Scale for Suicidal ideation, State Anxiety Scale of the State-Trait Anxiety Inventory, Beck Anxiety Inventory, and LDAEP (measured at electrode Cz). There were no sex-related differences among groups (p = 0.821). The high-suicidality group exhibited significantly higher LDAEP compared to the low-suicidality group (0.82 ± 0.79 vs. 0.26 ± 0.36, p = 0.014). No significant differences were found between the control and high-suicidality (p = 0.281) or the control and low-suicidality groups (p = 0.236). LDAEP was applied to demonstrate the association between serotonergic activity and suicidal ideation and suicide risk in major depression and may be a candidate of biological marker for preventing suicide in this study.