Ovulation by repeated human chorionic gonadotrophin in 'empty follicle syndrome' yields a twin clinical pregnancy.
Ovulation by repeated human chorionic gonadotrophin in 'empty follicle syndrome' yields a twin clinical pregnancy.
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DOI：
10.1093/humrep/12.3.454
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发表时间：
1997-03
影响因子：
6.1
通讯作者：
F. Ubaldi;Z. Nagy;Cécile Janssenwillen;J. Smitz;A. V. Steirteghem;P. Devroey
中科院分区：
文献类型：
--
作者：
F. Ubaldi;Z. Nagy;Cécile Janssenwillen;J. Smitz;A. V. Steirteghem;P. Devroey
这个案例说明了在“空卵泡综合征”的情况下，在第二次排卵剂量的人绒毛膜促性腺激素(HCG)注射后，获得正常受精和卵裂的卵母细胞的可能性。本患者接受促性腺激素释放激素类似物(GnRHa)/促性腺激素促性腺激素卵胞浆内单精子注射(ICSI)的卵巢刺激。第一次取卵失败后，再次注射人绒毛膜促性腺激素促排卵。第二次取卵13枚，获得优质胚胎11枚，受精率和卵裂率分别为92%和91%。移植3个胚胎后无一例妊娠。在随后用克罗米芬刺激的周期中，三个冷冻解冻的胚胎被替换，并实现了双胞胎怀孕。这位病人足月产下了两个健康的婴儿。
This case illustrates the possibility of obtaining oocytes that fertilize and cleave normally after the administration of a second ovulatory dose of human chorionic gonadotrophin (HCG) in a case of 'empty follicle syndrome'. The present patient underwent ovarian stimulation with gonadotrophin-releasing hormone analogue (GnRHa)/menotropin for intracytoplasmic sperm injection (ICSI). After the failure of the first oocyte retrieval, a second dose of HCG was administered to trigger ovulation. A total of 13 oocytes was retrieved during the second procedure and 11 good quality embryos were obtained (fertilization and cleavage rates of 92 and 91% respectively). No pregnancy was achieved after the replacement of three embryos. In a subsequent cycle stimulated with clomiphene citrate, three frozen-thawed embryos were replaced and a twin pregnancy was achieved. The patient delivered two healthy babies at term.