Nitric oxide signaling in the microcirculation.
Nitric oxide signaling in the microcirculation.
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DOI：
10.1615/critrevbiomedeng.v39.i5.40
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发表时间：
2011
影响因子：
--
通讯作者：
Jaron D
中科院分区：
文献类型：
--
作者：
Buerk DG;Barbee KA;Jaron D
当人们将一氧化氮(NO)在血管结构中扩散和对流的模型的数学预测与动物和人类研究中对NO(或相关代谢物)的实验测量进行比较时，几个明显的悖论是显而易见的。从数学模型预测的NO值通常比体内低得多，没有文献报道的实验值，特别是在微循环中不同大小的血管旁边的血管周围位置没有微电极，也没有电极插入由所研究的每个特定器官系统的微循环供应的广泛组织中。关于血红蛋白清除NO的作用和保存NO的储存功能的作用仍然存在不确定性，其他信号靶标也不需要考虑。这篇综述描述了微循环中涉及NO的几个信号通路的模型预测和相关实验数据。
Several apparent paradoxes are evident when one compares mathematical predictions from models of nitric oxide (NO) diffusion and convection in vasculature structures with experimental measurements of NO (or related metabolites) in animal and human studies. Values for NO predicted from mathematical models are generally much lower than in vivo NO values reported in the literature for experiments, specifically with NO microelectrodes positioned at perivascular locations next to different sizes of blood vessels in the microcirculation and NO electrodes inserted into a wide range of tissues supplied by the microcirculation of each specific organ system under investigation. There continues to be uncertainty about the roles of NO scavenging by hemoglobin versus a storage function that may conserve NO, and other signaling targets for NO need to be considered. This review describes model predictions and relevant experimental data with respect to several signaling pathways in the microcirculation that involve NO.