Potential Blood Biomarker for Disease Severity in the Taiwanese Population With Alzheimer's Disease
Potential Blood Biomarker for Disease Severity in the Taiwanese Population With Alzheimer's Disease
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DOI：
10.1177/1533317512467674
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发表时间：
2013-02-01
影响因子：
3.4
通讯作者：
Cheng, Irene H.
中科院分区：
文献类型：
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作者：
Huang, Ching-Wen;Wang, Shang-Jang;Cheng, Irene H.
阿尔茨海默病(AD)血液标志物的识别有助于提高早期诊断水平。为了确定AD生物标志物，我们比较了AD组和非AD组血清/血浆中淀粉样β蛋白(Aβ)、tau、细胞因子和生物金属的水平。采用简易智力状态检查(MMSE)和临床痴呆评定量表评定认知功能障碍。用免疫分析法检测血浆总Aβ、Aβ(42)、肿瘤坏死因子-α(TNF-α)和白介素6的浓度。用火焰原子吸收光谱法测定血清生物金属浓度。我们发现AD患者的血清锌水平较低。在控制年龄后，AD组的MMSE评分与肿瘤坏死因子-α和总Aβ水平均相关，而非AD组的MMSE评分仅与铁相关。我们发现血锌、肿瘤坏死因子-α和总Aβ可能是AD诊断和预后的生物标记物，这证实了先前在台湾人群中发表的潜在生物标记物。
The identification of blood biomarkers for Alzheimer's disease (AD) could contribute for improvement in early diagnosis. To define AD biomarkers, we compared serum/plasma levels of amyloid beta (A beta), tau, cytokines, and biometals between AD and non-AD groups. Cognitive impairment was assessed by Mini-Mental Status Examination (MMSE) and Clinical Dementia Rating scales. Plasma concentrations of total A beta, A beta(42), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 were quantified by immunoassays. Serum biometal concentrations were determined using flame atomic absorption spectrometry. We found that serum zinc (Zn) was lower in patients with AD. After controlling for age, the MMSE score correlated with both TNF-alpha and total A beta levels in the AD group, while the MMSE score correlated with iron only in the non-AD group. Our finding that blood Zn, TNF-alpha, and total A beta are possible biomarkers for AD diagnosis and prognosis validates the pervious publication on potential biomarker in the Taiwanese population.