Hypermagnesemia does not increase brain intracellular magnesium in newborn swine
Hypermagnesemia does not increase brain intracellular magnesium in newborn swine
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DOI：
10.1016/s0887-8994(01)00317-4
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发表时间：
2001-10-01
影响因子：
3.8
通讯作者：
Laptook, AR
中科院分区：
文献类型：
--
作者：
Gee, JB;Corbett, RJT;Laptook, AR
在2日龄（n = 4）和40日龄（n = 4）小型猪中使用磷-31磁共振波谱来确定血浆高镁血症是否改变脑细胞内镁浓度以及血浆-脑细胞内镁关系是否随年龄而变化。在对照组中，2天组（0.24 +/- 0.04 mM）和40天组（0.21 +/- 0.01 mM）的脑细胞内镁浓度相似。静脉输注硫酸镁（MgSO 4，60分钟）使两组的血浆镁浓度升高至4-6 mM。在MgSO 4输注期间和输注后3小时，两组脑细胞内镁浓度均无变化，血浆和脑细胞内镁之间无相关性（2天和40天组分别为r = 0.11和0.08）。脑细胞内镁浓度似乎受到严格的调节。(C)2001年，Elsevier Science Inc. All rights reserved.
Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intracellular magnesium concentration was similar in the 2-day (0.24 +/- 0.04 mM) and 40-day groups (0.21 +/- 0.01 mM). Intravenous infusions of magnesium sulfate (MgSO4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO4 infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated. (C) 2001 by Elsevier Science Inc. All rights reserved.