POSTNATAL HUMAN-LUNG GROWTH
POSTNATAL HUMAN-LUNG GROWTH
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DOI：
10.1136/thx.37.8.564
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发表时间：
1982-01-01
期刊：
影响因子：
10
通讯作者：
THURLBECK, WM
中科院分区：
文献类型：
--
作者：
THURLBECK, WM
对 36 名男孩和 20 名女孩的肺部应用了标准形态测量方法，年龄从 6 周到 14 岁，这些男孩因外伤或短暂患病而死亡。男孩和女孩之间的个体肺单位、肺泡尺寸以及每单位面积和体积的肺泡数量没有差异，但对于相同身材，男孩的肺比女孩大。这导致在给定年龄和身材下，男孩的肺泡总数和肺泡表面积比女孩更大。男孩的呼吸细支气管可能比女孩多。出生后2年内肺泡迅速增殖，肺泡尺寸以及单位面积和体积的肺泡数量在此期间没有太大变化。两岁后肺泡总数几乎没有增加或没有增加，但数据很难解释。生长中的肺中肺泡总数分布广泛，这与成人肺泡总数变化很大的观察结果一致。给出了所研究的各种形态测量变量的预测数据。
Standard morphometric methods were applied to the lungs of 36 boys and 20 girls aged from 6 wk to 14 yr, dying as a result of trauma or after short illnesses. Individual lung units, alveolar dimensions and number of alveoli per unit area and volume did not differ between boys and girls, but boys had bigger lungs than girls for the same stature. This resulted in a larger total number of alveoli and a larger aveolar surface area in boys than in girls for a given age and stature. There may be more respiratory bronchioles in boys than girls. There was rapid alveolar multiplication during the first 2 yr of life, and alveolar dimensions and number of alveoli per unit area and volume did not change much during this period. There was little or no increase in the total number of alveoli after the age of 2 yr but the data are hard to interpret. There is a wide scatter of the total number of alveoli in the growing lung, in keeping with the observation that the total number of alveoli is very variable in adults. Prediction data are given for the various morphometric variables studied.