Association of coffee and caffeine intake with the risk of Parkinson disease
Association of coffee and caffeine intake with the risk of Parkinson disease
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DOI：
10.1001/jama.283.20.2674
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发表时间：
2000-05-24
影响因子：
120.7
通讯作者：
White, LR
中科院分区：
文献类型：
--
作者：
Ross, GW;Abbott, RD;White, LR
背景在未来的几十年里，帕金森病（PD）高危老年人群的预计扩张使得识别促进或预防该疾病的因素成为一个重要的goat.Objective.Objective探讨咖啡和膳食咖啡因摄入量与PD风险的关系。数据分析来自8004名日裔美国男性30年的随访（年龄45-68岁）在1965年至1968年期间参加了前瞻性纵向檀香山心脏计划。主要结果测量事件PD，通过咖啡摄入量（在研究登记和6年随访时测量）和总饮食咖啡因摄入量（在登记时测量）。随着咖啡摄入量的增加，帕金森病的发病率也随之下降，从不喝咖啡的男性的10.4/10000人-年下降到每天喝至少28盎司咖啡的男性的1.9/10000人-年（P <0.05）。
Context The projected expansion in the next several decades of the elderly population at highest risk for Parkinson disease (PD) makes identification of factors that promote or prevent the disease an important goat.Objective To explore the association of coffee and dietary caffeine intake with risk of PD.Design, Setting, and Participants Data were analyzed from 30 years of fallow-up of 8004 Japanese American men (aged 45-68 years) enrolled in the prospective longitudinal Honolulu Heart Program between 1965 and 1968.Main Outcome Measure Incident PD, by amount of coffee intake (measured at study enrollment and 6-year follow-up) and by total dietary caffeine intake (measured at enrollment).Results During follow-up, 102 men were identified as having PD. Age-adjusted incidence of PD declined consistently with increased amounts of coffee intake, from 10.4 per 10000 person-years in men who drank no coffee to 1.9 per 10000 person-years in men who drank at least 28 oz/d (P