CONDITIONING POLYTETRAFLUOROETHYLENE SURFACES FOR USE IN VASCULAR PROSTHESES
CONDITIONING POLYTETRAFLUOROETHYLENE SURFACES FOR USE IN VASCULAR PROSTHESES
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DOI：
10.1002/app.1970.070140201
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发表时间：
1970-01-01
影响因子：
3
通讯作者：
KAPLIT, MJ
中科院分区：
文献类型：
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作者：
MILLER, ML;POSTAL, RH;KAPLIT, MJ
聚四氟乙烯表面已经过处理以减少血栓形成性，以便使其适合用于与血液接触的假体装置。首先用钾在液氨中蚀刻表面，产生双键，然后用这些双键作为聚酸接枝的位置或作为化学反应的位置。将处理后的导管植入狗的胸主动脉或下腔静脉，检测其血栓形成活性。这些试验表明，只要这些基团的表面浓度不太高（每平方厘米几何面积的1-2 × 10−6等量），并且这些基团的分布均匀，就可以通过附着带负电荷的基团来降低聚四氟乙烯表面的血栓形成性。氯磺化得到的磺酸基团和接枝巴豆酸叔丁酯水解得到的羧基是有效的。长链聚（丙烯酸）、聚（乙烯磺酸）和聚（乙烯醇）硫酸盐的效果较差。
Polytetrafluoroethylene surfaces have been treated to reduce thrombogenicity in order to make them suitable for use in prosthetic devices that come in contact with blood. This was done by first etching the surface with potassium in liquid ammonia to produce double bonds and then using these double bonds as sites for grafting on polyacids or as sites for chemical reactions. Tubes so treated were tested for thrombo‐genetic activity by implantation in the thoracic aorta or inferior vena cava of dogs. These tests showed that the thrombogenicity of a polytetrafluoroethylene surface can be reduced by attaching negatively charged groups provided the surface concentration of these groups is not too high (order of 1–2 × 10−6equivalent per cm2geometric area) and provided the distribution of these groups is uniform. Sulfonic acid groups obtained by chlorosulfonation and carboxyl groups attached by graftingtert‐butyl crotonate and hydrolyzing to crotonic acid were effective. Long chains of poly(acrylic acid), poly‐(ethylenesulfonic acid), and poly(vinyl alcohol) sulfate were less effective.