The prevalence of glucose intolerance in Japanese schizophrenic patients with a normal fasting glucose level.
The prevalence of glucose intolerance in Japanese schizophrenic patients with a normal fasting glucose level.
复制标题
空腹血糖水平正常的日本精神分裂症患者中葡萄糖不耐受的患病率。
DOI：
10.1097/jcp.0b013e3182905775
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Someya T.
中科院分区：
文献类型：
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作者：
Ono S;Suzuki Y;Fukui N;Sugai T;Watanabe J;Tsuneyama N;Saito M;Someya T.
背景精神分裂症患者糖尿病的患病率是普通人群的2- 3倍。在最近一项包括空腹血糖监测的横断面研究中，11.9%的日本精神分裂症患者检测到血糖异常。然而，在日本精神分裂症患者中，使用葡萄糖耐量试验进行的葡萄糖耐量不耐受的详细研究有限。我们调查了日本精神分裂症住院患者糖负荷后糖耐量异常的患病率，空腹血糖水平正常。MethodA共258例精神分裂症住院患者在给予书面知情同意后参加了这项研究。结果空腹血糖正常的患者中，糖耐量正常者占81.3%，糖耐量受损者占17.3%，1.3%结论空腹血糖正常的精神分裂症患者糖耐量异常的发生率可能更高比一般人多。因此，可能有必要仔细监测和筛查精神分裂症患者的糖代谢异常。
BackgroundThe prevalence of diabetes in patients with schizophrenia is 2-to 3-fold higher than in the general population. Glucose abnormalities were detected in 11.9% of Japanese schizophrenic patients in a recent cross-sectional study that included fasting glucose monitoring. However, detailed studies of glucose intolerance using the glucose tolerance test have been limited in Japanese patients with schizophrenia. We investigated the prevalence of abnormal glucose tolerance after glucose loading among Japanese inpatients with schizophrenia, with normal fasting glucose levels.MethodA total of 258 inpatients with schizophrenia participated in this study after giving their written informed consent. A 75-g oral glucose tolerance test was conducted in the morning after a 12-hour overnight fast.ResultsAmong patients with normal fasting glucose, 81.3% had normal glucose tolerance, 17.3% had impaired glucose tolerance, and 1.3% were diagnosed with diabetes.ConclusionsThis study showed that the frequency of impaired glucose tolerance in patients with schizophrenia with normal fasting glucose levels might be higher than in the general population. Careful monitoring and screening of patients with schizophrenia for abnormal glucose metabolism might therefore be necessary.