Sympathectomy decreases size and invasiveness of tongue cancer in rats
Sympathectomy decreases size and invasiveness of tongue cancer in rats
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DOI：
10.1016/j.neuroscience.2007.07.048
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发表时间：
2007-11-09
期刊：
影响因子：
3.3
通讯作者：
Heyeraas, K. J.
中科院分区：
文献类型：
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作者：
Raju, B.;Haug, S. R.;Heyeraas, K. J.
交感神经系统在肿瘤发生中起作用，局部释放的交感神经递质影响增殖、血管生成、血管通透性、淋巴细胞运输和细胞因子的产生。本研究旨在探讨手术切除单侧和双侧交感神经对大鼠舌癌肿瘤生长、间质液体压(IFP)和淋巴管的影响。我们用饮水中的4-硝基喹啉-1-氧化物(4-NQO)对20只Dark Agti大鼠进行了19周的舌癌诱导。11周后，一组接受单侧交感神经切除术，另一组接受双侧交感神经切除术，第三组接受假手术。19周时，双侧交感神经切除组(BL-SCGx)肿瘤体积明显减小(P
The sympathetic nervous system plays a role in carcinogenesis wherein locally released sympathetic neurotransmitters affect proliferation, angiogenesis, vessel permeability, lymphocyte traffic and cytokine production. The present in vivo study was designed to investigate whether surgical sympathectomy, both unilateral and bilateral, had an effect on tumor growth, interstitial fluid pressure (IFP) and lymphatics in rat tongue cancer. We used 4-nitroquinoline-1 -oxide (4-NQO) in drinking water for 19 weeks to induce tongue cancer in 20 Dark Agouti rats. After 11 weeks, one group underwent unilateral sympathectomy and another underwent bilateral sympathectomy, while the third group underwent sham surgery. By 19 weeks, tumors in the bilaterally sympathectomized (BL-SCGx) rats were significantly smaller (P