Rab37 is a novel mast cell specific GTPase localized to secretory granules
Rab37 is a novel mast cell specific GTPase localized to secretory granules
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DOI：
10.1016/s0014-5793(00)01288-6
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发表时间：
2000-03-17
期刊：
影响因子：
3.5
通讯作者：
Scheller, RH
中科院分区：
文献类型：
--
作者：
Masuda, ES;Luo, Y;Scheller, RH
gtpase调节无数的细胞功能，包括信号转导，细胞骨架组织和膜运输。Rab gtpase通过组织和调节在囊泡运输中重要的效应蛋白的活性来协调细胞的膜动力学。Rab37是在MC-9肥大细胞系和骨髓肥大细胞中特异表达的一种新型Rab GTPase，其与Rab26的同源性为74%，与Rabs的同源性为47%，是哺乳动物细胞中高尔基体对质膜囊泡运输的重要GTPase。当绿色荧光蛋白标记的Rab37在骨髓肥大细胞中表达时，分泌颗粒被标记。这些数据表明Rab37可能在肥大细胞脱颗粒中发挥重要作用，使其成为过敏治疗干预的潜在重要靶点。(C) 2000年欧洲生化学会联合会。
GTPases regulate a myriad of cellular functions including signal transduction, cytoskeletal organization and membrane trafficking. Rab GTPases act to coordinate the membrane dynamics of cells by organizing and regulating the activity of effector proteins important in vesicle trafficking. Rab37 is a novel Rab GTPase specifically expressed in the MC-9 mast cell line and bone marrow mast cells, Rab37 is 74% identical to Rab26 and 47% identical to Rabs, a GTPase important in Golgi to plasma membrane vesicle trafficking in mammalian cells, When green fluorescent protein tagged Rab37 is expressed in bone marrow mast cells, the secretory granules are labeled. These data suggest that Rab37 may play an important role in mast cell degranulation making this protein a potentially important target for therapeutic intervention in the treatment of allergy. (C) 2000 Federation of European Biochemical Societies.