An intimate link: two-component signal transduction systems and metal transport systems in bacteria.
An intimate link: two-component signal transduction systems and metal transport systems in bacteria.
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DOI：
10.2217/fmb.14.87
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发表时间：
2014
影响因子：
3.1
通讯作者：
Cvitkovitch DG
中科院分区：
文献类型：
--
作者：
Singh K;Senadheera DB;Cvitkovitch DG
细菌已经进化出各种策略来应对高浓度的环境重金属离子，以快速适应性反应来维持细胞活力。在过去的二十年中收集的证据表明，细菌的双组分信号转导系统（TCSTS）密切参与监测阳离子的积累，并可以调节相关的代谢和毒力基因的表达，引起适应性反应，这些离子的浓度变化。使用最近的研究中获得的例子，我们总结了金属离子和TCSTS之间的交叉调节关系。我们目前的证据表明，细菌TCSTS如何调节金属离子的稳态，以及金属离子，反过来，功能来控制这些信号系统的活动与细菌的生存和毒力。
Bacteria have evolved various strategies to contend with high concentrations of environmental heavy metal ions for rapid, adaptive responses to maintain cell viability. Evidence gathered in the past two decades suggests that bacterial two-component signal transduction systems (TCSTSs) are intimately involved in monitoring cation accumulation, and can regulate the expression of related metabolic and virulence genes to elicit adaptive responses to changes in the concentration of these ions. Using examples garnered from recent studies, we summarize the cross-regulatory relationships between metal ions and TCSTSs. We present evidence of how bacterial TCSTSs modulate metal ion homeostasis and also how metal ions, in turn, function to control the activities of these signaling systems linked with bacterial survival and virulence.