STRUCTURAL RELATIONSHIPS AMONG GENES THAT CONTROL DEVELOPMENT - SEQUENCE HOMOLOGY BETWEEN THE ANTENNAPEDIA, ULTRABITHORAX, AND FUSHI TARAZU LOCI OF DROSOPHILA
STRUCTURAL RELATIONSHIPS AMONG GENES THAT CONTROL DEVELOPMENT - SEQUENCE HOMOLOGY BETWEEN THE ANTENNAPEDIA, ULTRABITHORAX, AND FUSHI TARAZU LOCI OF DROSOPHILA
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DOI：
10.1073/pnas.81.13.4115
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
WEINER, AJ
中科院分区：
文献类型：
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作者：
SCOTT, MP;WEINER, AJ
调节果蝇发育的基因D.在至少2例中，黑腹菌以紧密相连的簇存在。这些簇，双胸复合体（BX-C）和双足复合体（ANT-C），都含有多个同源异型基因座：每个基因座的突变导致果蝇的一部分转化为另一部分。几个重复的DNA序列，包括至少一个转座子，被定位在ANT-C。来自ANT-C中的同源异型基因座Anctapedia（Antp）的3“外显子的DNA与来自BX-C中的同源异型基因座Ultrabithorax（Ubx）的3”外显子的DNA弱杂交。来自这些3“外显子中的每一个的DNA也与来自ANT-C的fushi tarazu基因座的DNA弱杂交。fushi tarazu（ftz）基因座控制着发育中胚胎体节的数量和分化。对3个位点的交叉杂交DNA进行序列分析，结果表明，来自基因编码部分的预测氨基酸序列是保守的。显然，2个同源异型位点和一个片段缺失位点编码具有部分共享结构的蛋白质产物，这3个位点可能在进化和功能上相关。
Genes that regulate the development of the fruit fly D. melanogaster exist as tightly linked clusters in at least 2 cases. These clusters, the bithorax complex (BX-C) and the Antennapedia complex (ANT-C), both contain multiple homeotic loci: mutations in each locus cause a transformation of one part of the fly into another. Several repetitive DNA sequences, including at least one transposon, were mapped in the ANT-C. DNA from the 3'' exon of Antennapedia (Antp), a homeotic locus in the ANT-C, hybridized weakly to DNA from the 3'' exon of Ultrabithorax (Ubx), a homeotic locus in the BX-C. DNA from each of these 3'' exons also hybridized weakly to DNA from the fushi tarazu locus of the ANT-C. The fushi tarazu (ftz) locus controls the number and differentiation of segments in the developing embryo. Sequence analysis of the cross-hybridizing DNA from the 3 loci revealed the conservation of predicted amino acid sequences derived from coding parts of the genes. Apparently, 2 homeotic loci and a segment-deficient locus encode protein products with partially shared structures and the 3 loci may be evolutionarily and functionally related.