A Fungal Promiscuous UbiA Prenyltransferase Expands the Structural Diversity of Chrodrimanin-Type Meroterpenoids.
A Fungal Promiscuous UbiA Prenyltransferase Expands the Structural Diversity of Chrodrimanin-Type Meroterpenoids.
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DOI：
10.1021/acs.orglett.2c00495
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发表时间：
2022-03
期刊：
影响因子：
5.2
通讯作者：
Kaijin Zhang;Guojian Zhang;Xuewen Hou;Chuanteng Ma;Junyu Liu;Qian Che;T. Zhu;Dehai Li
中科院分区：
文献类型：
--
作者：
Kaijin Zhang;Guojian Zhang;Xuewen Hou;Chuanteng Ma;Junyu Liu;Qian Che;T. Zhu;Dehai Li
戊烯基转移酶在天然产物的多样化和生物活性的提高方面发挥着重要作用。具有底物混杂性的ubia型戊烯基转移酶CdnC被确定为非典型染色质骨架的关键构建者，其非萜部分携带苯并环己酮结构。CdnC的体外和异源表达研究导致了一系列新的染色质样结构的产生。CdnC的发现为法尼基衍生的美罗萜类化合物的生物合成和结构多样化提供了可参考的策略。
Prenyltransferases play important roles in the diversification of natural products and the improvement of biological activities. A UbiA-type prenyltransferase CdnC with substrate promiscuity was identified as the pivotal builder of the noncanonical chrodrimanin skeletons, which carry a benzo-cyclohexanone structure as the nonterpene part. In vitro and heterologous expression studies with CdnC led to the production of a series of novel chrodrimanin-like structures. The discovery of CdnC offers a referable strategy for the biosynthesis and structural diversification of farnesyl-derived meroterpenoids.