Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.
Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.
复制标题
分泌型卷曲相关蛋白 3 (sFRP3) 在发育中的小鼠脊髓和背根神经节中的动态表达
DOI：
10.1016/j.neuroscience.2013.06.044
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发表时间：
2013-09-17
期刊：
影响因子：
3.3
通讯作者：
Qiu M
中科院分区：
文献类型：
--
作者：
Zhao X;Huang H;Chen Y;Liu Y;Zhang Z;Ma Q;Qiu M
Wnt 蛋白参与调节中枢神经系统 (CNS) 的多种发育过程。分泌型卷曲相关蛋白 3 (sFRP3) 是 sFRP 家族的成员，可通过与卷曲蛋白 Wnt 结合域同源的区域直接与 Wnt 结合，从而抑制 Wnt 信号传导。最近的研究表明sFRP3在多种组织的细胞增殖和分化中发挥着重要作用。为了了解 sFRP3 在神经发育中的作用，我们对发育中的神经系统中 sFRP3 的表达进行了详细的研究。我们的结果显示，sFRP3 最初在脊髓的心室区和背根神经节 (DRG) 中表达，后来在脊髓的背角和 DRG 神经元亚群中表达。 sFRP3 的时空动态表达强烈表明 sFRP3 在感觉神经元发生和感觉回路形成中具有潜在功能。
Wnt proteins have been implicated in regulating a variety of developmental processes in the central nervous system (CNS). Secreted Frizzled-related protein 3 (sFRP3) is a member of the sFRP family that can inhibit the Wnt signaling by binding directly to Wnts via their regions of homology to the Wnt-binding domain of Frizzleds. Recent studies suggested that sFRP3 plays an important role in cell proliferation and differentiation in various tissues. To understand the role of sFRP3 in neural development, we carried out detailed studies on the expression of sFRP3 in the developing nervous system. Our results revealed that sFRP3 is initially expressed in the ventricular zone of spinal cord and dorsal root ganglia (DRG), and later in the dorsal horn of spinal cord and subpopulation of DRG neurons. The spatiotemporally dynamic expression of sFRP3 strongly suggests that sFRP3 has potential functions in the sensory neuron genesis and sensory circuitry formation.