Age-related normative values of trabecular bone score (TBS) for Japanese women: the Japanese Population-based Osteoporosis (JPOS) study
Age-related normative values of trabecular bone score (TBS) for Japanese women: the Japanese Population-based Osteoporosis (JPOS) study
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DOI：
10.1007/s00198-014-2856-5
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发表时间：
2015-01-01
影响因子：
4
通讯作者：
Yoneshima, H.
中科院分区：
文献类型：
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作者：
Iki, M.;Tamaki, J.;Yoneshima, H.
骨小梁评分（TBS）是骨微结构的替代测量，独立于骨密度代表骨折风险。我们从日本妇女的代表性人口研究中提出规范的TBS值。该数据库将提高我们对骨小梁微结构的认识，并改善骨质疏松症的治疗。TBS是一种纹理参数，用于量化腰椎双能x线吸收仪（DXA）图像中灰度分布的局部变化。虽然TBS与骨折风险独立于面骨矿物质密度（aBMD）相关，但规范的TBS值仅在白种人女性中有报道。本研究从日本女性的代表性样本中提供了年龄特异性的TBS规范值。我们从日本7个地区随机选择了4550名年龄在15-79岁之间的女性。年龄小于20岁的妇女和有任何可能影响骨代谢的病史的妇女被排除在外，剩余的3,069名从第一到第四椎骨至少有两个可评估的椎骨被分析。使用TBS iNsight软件（Med-Imaps，法国）从脊柱DXA图像计算TBS值。采用分段线性回归分析方法建立TBS的年龄相关模型。参与者年龄、体重指数（BMI）、脊柱aBMD和TBS（平均+/- SD）分别为48.7 +/- 16.8岁、22.9 +/- 3.4岁、0.888 +/- 0.169 g/cm(2)和1.187 +/- 0.137岁。年龄对TBS的三段式线性回归模型解释了TBS总方差的70.7%，其中最年轻部分的年龄相关变化很小，中间部分损失迅速，最老部分损失较小。在所有年龄段中，日本女性的TBS都低于白种人女性，随着年龄的增长，这种差异在65岁之前会越来越大。本文介绍的日本女性TBS的规范性价值，将增强我们对骨小梁微结构的理解，并有助于改善骨质疏松症的治疗。
Trabecular bone score (TBS), a surrogate measure of bone microarchitecture, represents fracture risk independently of bone density. We present normative TBS values from a representative population study of Japanese women. This database would enhance our understanding of trabecular bone microarchitecture and improve osteoporosis management.TBS is a texture parameter that quantifies local variation in gray level distribution within dual-energy X-ray absorptiometry (DXA) images of the lumbar spine. While TBS is associated with fracture risk independently of areal bone mineral density (aBMD), normative TBS values have only been reported for Caucasian women. This study provides age-specific normative values of TBS from a representative sample of Japanese women.We randomly selected 4,550 women aged 15-79 years from 7 areas throughout Japan. Women younger than 20 years and those with any medical history which might affect bone metabolism were excluded, and the remaining 3,069 with at least two assessable vertebrae from the first to the fourth vertebrae were subjected to analysis. TBS values were calculated from spine DXA images using TBS iNsight software (Med-Imaps, France). Age-related models of TBS were constructed using piecewise linear regression analysis.Participant age, body mass index (BMI), spine aBMD, and TBS (mean +/- SD) were 48.7 +/- 16.8 years, 22.9 +/- 3.4, 0.888 +/- 0.169 g/cm(2), and 1.187 +/- 0.137, respectively. A three-piece linear regression model of TBS on age explained 70.7 % of the total variance in TBS and comprised very small age-related changes in the youngest segment of the regression line, rapid loss in the middle segment, and small loss in the oldest segment. TBS was lower in Japanese women than in Caucasian women across all age ranges, with the difference increasing with age up through 65 years.The normative values of TBS for Japanese women presented here would enhance our understanding of trabecular bone microarchitecture and help improve the management of osteoporosis.