Design and implementation of embedded 8-channel receive-only arrays for whole-brain MRI and fMRI of conscious awake marmosets.
Design and implementation of embedded 8-channel receive-only arrays for whole-brain MRI and fMRI of conscious awake marmosets.
复制标题
设计和实现嵌入式 8 通道仅接收阵列，用于清醒狨猴的全脑 MRI 和 fMRI。
DOI：
10.1002/mrm.26339
复制
发表时间：
2017
影响因子：
3.3
通讯作者：
Silva,AfonsoC
中科院分区：
文献类型：
--
作者：
Papoti,Daniel;Yen,CecilChern-Chyi;Hung,Chia-Chun;Ciuchta,Jennifer;Leopold,DavidA;Silva,AfonsoC
目的恒河猴(Callithrix Jacchus)是新大陆的一种灵长类动物，在神经科学和脑翻译研究中日益受到人们的关注。本工作描述了个性化的8通道仅接收射频(RF)线圈阵列的设计和实现，该阵列提供全脑覆盖，并允许在清醒的恒河猴中进行解剖和功能磁共振实验。线圈元件的大小、几何形状和排列进行了优化，以实现全脑覆盖。线圈到线圈的解耦通过几何解耦和低输入阻抗前置放大器的组合来实现。结果为3只绒猴制作了3种个性化的内嵌线圈阵列头盔。实现了全脑覆盖，并将高灵敏度扩展到整个皮质。清醒绒猴的视觉刺激在枕颞皮质的初级和高阶视觉区域都能引起强烈的fMRI反应。结论嵌入式只接收线圈阵列提供的高灵敏度使得清醒的绒猴可以获得高空间分辨率的解剖和功能MRI数据。Magn Reson Med 78：387-398,2017。2016年国际核磁共振医学学会
PurposeThe common marmoset (Callithrix jacchus) is a New World primate of increasing interest to neuroscience and in translational brain research. The present work describes the design and implementation of individualized 8‐channel receive‐only radiofrequency (RF) coil arrays that provide whole‐brain coverage and allow anatomical and functional MRI experiments in conscious, awake marmosets.MethodsThe coil arrays were designed with their elements embedded inside individualized restraint helmets. The size, geometry, and arrangement of the coil elements were optimized to allow whole‐brain coverage. Coil‐to‐coil decoupling was achieved by a combination of geometric decoupling and low input impedance preamplifiers. The performance of the embedded arrays was compared against that of one 8‐channel receive‐only array built to fit the external surface of the helmets.ResultsThree individualized helmets with embedded coil arrays were built for three marmosets. Whole‐brain coverage was achieved with high sensitivity extending over the entire cortex. Visual stimulation of conscious awake marmosets elicited robust BOLD fMRI responses in both primary and higher order visual areas of the occipitotemporal cortex.ConclusionThe high sensitivity provided by embedded receive‐only coil arrays allows both anatomical and functional MRI data to be obtained with high spatial resolution in conscious, awake marmosets. Magn Reson Med 78:387–398, 2017. © 2016 International Society for Magnetic Resonance in Medicine