Ovarian Tumors in Children and Adolescents-A Clinical Study of 52 Patients in a University Hospital
Ovarian Tumors in Children and Adolescents-A Clinical Study of 52 Patients in a University Hospital
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DOI：
10.1016/j.jpag.2010.06.005
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发表时间：
2011-02-01
影响因子：
1.8
通讯作者：
Rahman, Mohammad S.
中科院分区：
文献类型：
--
作者：
Al Jama, Fathia E.;Al Ghamdi, Ahlam A.;Rahman, Mohammad S.
研究目的：回顾1985年1月至2009年12月在沙特阿拉伯达曼大学法哈德国王医院妇产科就诊的儿童和青少年卵巢肿瘤的临床表现。设计：从医院病历中回顾患者的年龄、临床表现、诊断、治疗和结果。地点：本研究于1985-01/2009-12在沙特阿拉伯达曼大学法哈德国王医院妇产科完成。研究对象：在研究期间，52名6~20岁的患者出现卵巢肿瘤。干预：术前诊断方法包括病史、体格检查、超声检查、放射学检查、肿瘤标志物、手术治疗、肿瘤的组织病理学检查。结果：30例(58%)患者以腹痛为主要表现。在肿瘤中，87%为生殖细胞肿瘤，其中73%为良性，13%为恶性。手术方式包括开腹探查48例(92%)，腹腔镜手术4例(8%)。卵巢膀胱切除23例(44%)，输卵管卵巢切除28例(54%)。7例(13%)恶性肿瘤患者中，5例接受术后化疗。3例恶性肿瘤患者死亡。结论：年轻女孩卵巢肿块的早期诊断具有重要意义。由于这些肿块大多是良性的，手术应该设计为优化未来的生育能力，而恶性肿瘤的治疗将包括完全分期，肿瘤切除，术后化疗，以使患者有机会未来生育。
Study Objective: To review the clinical presentation of ovarian tumors in children and adolescents treated at the University of Dammam and King Fahad University Hospital.Design: Data of the patients was noted retrospectively from the hospital medical records regarding age, presentation, diagnosis, treatment, and outcome.Setting: The study was carried out in the Ob/Gyn department at King Fahad Hospital of Dammam University, Saudi Arabia between January 1985 and December 2009.Participants: There were 52 patients between 6 and 20 years of age who presented with an ovarian tumor during the study period.Intervention: Preoperative diagnostic approach included history, physical examination, ultrasonography, radiological examination, tumor markers, operative treatment, and histopathological examination of the tumor. Chemotherapy was given to patients where indicated.Results: The main presenting symptom was abdominal pain in 30 (58%) patients. Of the neoplastic tumors, 87% were germ cell tumors, of which 73% were benign while 13% were malignant. Operative procedures included 48 (92%) exploratory laparotomies and 4 (8%) laparoscopic resections. Ovarian cystectomy was clone in 23 (44%) patients and salpingoophorectomy in 28 (54%) patients. Of the 7 (13%) patients with malignant tumors, five received postoperative chemotherapy. Three patients with malignancy died in the series.Conclusion: Early diagnosis of ovarian masses in young girls is important. Since most of these masses are benign, operation should be designed to optimize future fertility, while the treatment of malignant tumors would involve complete staging, resection of the tumor, postoperative chemotherapy when indicated, to give the patient a chance for future childbearing.