Primary Hyperoxaluria
Primary Hyperoxaluria
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DOI：
10.1136/bmj.1.5168.259
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发表时间：
1960-01
影响因子：
--
通讯作者：
T. H. Shepard;Edwin G. Krebs;Lou-sein W. Lee;M. L. Johnson
中科院分区：
文献类型：
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作者：
T. H. Shepard;Edwin G. Krebs;Lou-sein W. Lee;M. L. Johnson
据报道，对一名原发性高草酸尿症患者进行了饮食和代谢研究。当他摄入低草酸盐、低抗坏血酸、镁或核黄素的饮食时，尿液中草酸盐的排泄量没有明显变化。高蛋白质和低碳水化合物的饮食与草酸盐排泄增加有关，而可的松和术后状态引起的蛋白质分解代谢增加并没有明显改变尿草酸盐排泄。草酸盐积累增加的来源可能与甘氨酸-乙醛酸-草酸盐途径有关的证据是，观察到服用苯甲酸钠略微抑制了母亲尿中草酸盐排泄的增加。甘氨酸（10 克）不会导致尿液中草酸盐明显增加，但可能与患者膀胱结石的形成有关。在氮排泄的大范围波动期间，尿液中草酸盐与氮的比率保持相对恒定。
Dietary and metabolic studies carried out on a patient with primary hyperoxaluria are reported. There was no appreciable change in the urinary excretion of oxalate when he was given a diet low in oxalate, or ascorbic acid, magnesium or riboflavin. A diet high in protein and low in carbohydrate was associated with increased excretion of oxalate, whereas increased catabolism of protein induced by cortisone and the postoperative state did not appreciably change the urinary excretion of oxalate. Evidence that the source of increased accumulation of oxalate might be related to the glycine-glyoxylate-oxalate pathway is the observation that the increased urinary excretion of oxalate in the mother was slightly depressed by the administration of sodium benzoate. Glycine (10 gm) did not cause an appreciable increase in oxalate in the urine but may have been associated with formation of bladder stones in the patient. The ratio of oxalate to nitrogen in the urine remained relatively constant during wide fluctuations in excretion of nitrogen.