Arteriolar blood flow pulsatility in a patient before and after implantation of an axial flow pump
Arteriolar blood flow pulsatility in a patient before and after implantation of an axial flow pump
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DOI：
10.1016/j.athoracsur.2004.12.030
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发表时间：
2006-03-01
影响因子：
4.6
通讯作者：
Pries, AR
中科院分区：
文献类型：
--
作者：
Habazettl, H;Kukucka, M;Pries, AR
在终末期缺血性心力衰竭患者计划植入轴流泵小动脉血流模式记录使用新型活体显微镜。术前小动脉血流速度脉动性强，直径12.8 μ m的小动脉血流速度约为7 ~ 16mm / s。在泵植入后，这种脉动性被消除，小动脉血流速度随着泵转速的变化而瞬间改变（例如，在直径8.9 μ m的小动脉中，5,000 rpm时为2 mm/s， 8,000 rpm时为3.5 mm/s）。这种流速振荡的缺乏可能对剪切应力调节的小动脉重塑有深远的长期影响。
In a patient with end stage ischemic heart failure scheduled for implantation of an axial flow pump small arteriolar flow pattern was recorded using a novel intravital microscope. Preoperative arteriolar blood flow velocity was highly pulsatile, ranging from about 7 to 16 mm per second in a 12.8 mu m diameter arteriole. After implantation of the pump, this pulsatility was abrogated and arteriolar blood flow velocity changed instantaneously with changes in pump speed (eg, 2 mm/s at 5,000 rpm vs; 3.5 mm/s at 8,000 rpm in an 8.9 mu m diameter arteriole). This lack of flow velocity oscillations may have profound long-term effects on shear stress regulated arteriolar remodeling.