Inhibition of macrophage migration by muramyl peptides
Inhibition of macrophage migration by muramyl peptides
复制标题
胞壁酰肽抑制巨噬细胞迁移
DOI：
10.1128/iai.24.2.308-312.1979
复制
发表时间：
1979
影响因子：
3.1
通讯作者：
S. Kotani
中科院分区：
文献类型：
--
作者：
S. Nagao;A. Tanaka;Y. Yamamoto;T. Koga;K. Onoue;T. Shiba;K. Kusumoto;S. Kotani
在毛细管迁移系统中，一种人工合成的胞壁酰二肽（MDP; N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺），是细菌细胞壁肽聚糖的一部分，可抑制正常豚鼠或大鼠腹腔渗出液巨噬细胞的迁移。来自植物乳杆菌和表皮葡萄球菌细胞壁的一些含MDP的肽聚糖片段也引起迁移抑制。不能根据巨噬细胞移动抑制因子解释移动抑制。MDP的佐剂活性所需的立体化学高度特异性结构也是巨噬细胞迁移抑制所需的。这些发现表明，MDP和MDP-含有细胞壁片段可以激活巨噬细胞，这种激活可能是重要的发挥其佐剂活性。
In the capillary tube migration system a synthetic muramyl dipeptide (MDP; N-acetylmuramyl-L-alanyl-D-isoglutamine), a part of bacterial cell wall peptidoglycans, inhibited the migration of peritoneal exudate macrophages from normal guinea pigs or rats. The migration inhibition was also caused by some MDP-containing peptidoglycan fragments from cell walls of Lactobacillus plantarum and Staphylococcus epidermidis. The migration inhibition could not be explained on the basis of macrophage migration inhibitory factor. A stereochemically highly specific structure of MDP required for its adjuvant activity was also required for the macrophage migration inhibition. These findings suggest that MDP and MDP-containing cell wall fragments may activate macrophages and that this activation may be important in the exertion of their adjuvant activity.