Structure and Tumor-promoting Activity of New Teleocidin-related Metabolites (Blastmycetins) from Streptoverticillium blastmyceticum
Structure and Tumor-promoting Activity of New Teleocidin-related Metabolites (Blastmycetins) from Streptoverticillium blastmyceticum
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芽霉菌链轮丝菌新的 Teleocidin 相关代谢物（芽霉菌素）的结构和促肿瘤活性
DOI：
10.1271/bbb1961.52.641
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
K. Koshimįzu
中科院分区：
文献类型：
--
作者：
N. Hagiwara;K. Irie;A. Funaki;H. Hayashi;M. Arai;K. Koshimįzu
从产促癌吲哚生物碱的发酵液中分离得到6个新的杀线菌素相关化合物(3~8)和(-)-N13-去甲基吲哚内酰胺V(9)。化合物3~8为(-)-吲哚内酰胺V(3)的二聚体，分别通过7位亚甲基键合在(-)-吲哚内酰胺V(4~7)和14-O-甲基硬脂素A-1(8)的2-氧基上。对它们的促肿瘤活性也进行了讨论。
Six new teleocidin-related compounds (3~8) together with (–)-N13-desmethylindolactam V(9) were found in the culture broth of Streptoverticillium blastmyceticum NA34-17 producing tumor-promoting indole alkaloids. Compounds 3 ~ 8 proved to be a dimer of (–)-indolactam V(3), which bound through a methylene group at position 7, 2-oxy derivatives of (–)-indolactam V(4~7) and 14-O-methylteleocidin A-1 (8), respectively. Their tumor-promoting activities are also discussed.