The role of brain fatty acids in pain
The role of brain fatty acids in pain
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DOI：
10.11154/pain.33.193
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发表时间：
2018-09
期刊：
影响因子：
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通讯作者：
K. Nakamoto;S. Tokuyama
中科院分区：
文献类型：
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作者：
K. Nakamoto;S. Tokuyama
随着脂肪酸分析技术的提高和精度的提高，越来越多的证据表明脂肪酸在多种生物现象中起着信号转导分子的作用。例如，最近的研究表明，脂肪酸的功能特性受脂肪酸个体摄入量、脂肪酸受体的鉴定及其表达变化、脂肪酸在器官中的分布等因素的调节。目前，多不饱和脂肪酸作为疼痛的调节因子之一，与疼痛的关系备受关注。N - 3脂肪酸可减轻炎症和神经病变引起的疼痛，而慢性疼痛患者血液中N - 6脂肪酸水平升高，从而加重疼痛。此外，我们提出脂肪酸受体可能作为疼痛的潜在靶分子。根据这些报告，脂肪酸很可能在调节疼痛中起主要作用。本文就脂肪酸作为新型疼痛治疗分子的研究现状及最新进展作一综述。
There is growing evidence that fatty acids function as signal transduction molecules in a variety of biological phenomena with improved technology and precision of fatty acids analysis. For example, recent study have revealed that the functional properties of fatty acids are modulated by the amount of individual fatty acid intake, identifica-tion of the fatty acid receptors and the changes of its expression, and the distribution of fatty acids among organs. Now, the relationship between polyunsaturated fatty acids and pain is getting a lot of attention as one of the modulation factor of pain. n– 3 fatty acids alleviate pain caused by inflammation and neuropathy, whereas blood levels of n– 6 fatty acids are increased in patients with chronic pain and thus exacerbate pain. Furthermore, we have proposed fatty acid receptors may function as a potential target molecule in pain. On the basis of these reports, it is likely that fatty acids play a major role in the regulation of pain. In this review, we discuss current status and our recent study regarding fatty acids as novel pain management molecules.