Biodegradable Stimuli-Responsive Polymeric Micelles for Treatment of Malignancy.
Biodegradable Stimuli-Responsive Polymeric Micelles for Treatment of Malignancy.
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DOI：
10.2174/138920101703160206142821
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发表时间：
2016
影响因子：
2.8
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Yan L;Li X
在过去的十年中，能够对肿瘤微环境或外部刺激做出反应的药物传递系统由于其提高的抗肿瘤功效和减少的副作用而成为治疗恶性肿瘤的有希望的平台。特别是可生物降解聚合物胶束已引起越来越多的关注，并迅速发展成为一种独特的治疗方法，以克服传统化疗抗癌药物的局限性。由于胶束系统在生物相容性、可降解性、循环时间和肿瘤蓄积方面的优势，在过去的几年里，人们一直致力于开发和优化胶束系统。本文综述了由可生物降解多肽和聚酯制成的刺激反应胶束作为纳米药物载体的最新进展，并特别限制了用于安全有效的癌症化疗的pH敏感，氧化还原敏感和光敏胶束体系的内容。
In the past decade, drug delivery systems that can respond to the tumor microenvironment or external stimuli have emerged as promising platforms for treating malignancies due to their improved antitumor efficacy and reduced side effects. In particular, biodegradable polymeric micelles have attracted increasing attention and been rapidly developed as a distinct therapeutic to overcome limitations of conventional chemotherapeutic anticancer drugs. Because of their advantages with respect to biocompatibility, degradability, circulation time, and tumor accumulation, considerable effort has been dedicated to the developing and optimizing micellar systems during the past few years. This review highlights recent advances concerning stimuli-responsive micelles made of biodegradable polypeptide and polyester as nanocarries for drug delivery, and especially limits the content to pH sensitive, redox sensitive, and photo-sensitive micellar systems for safe and efficient cancer chemotherapy.