Diverse DNA-Cleaving Capacities of the Jadomycins through Precursor-Directed Biosynthesis
Diverse DNA-Cleaving Capacities of the Jadomycins through Precursor-Directed Biosynthesis
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DOI：
10.1021/ol902907r
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发表时间：
2010-03-19
期刊：
影响因子：
5.2
通讯作者：
McFarland, Sherri A.
中科院分区：
文献类型：
--
作者：
Cottreau, Kristal M.;Spencer, Colin;McFarland, Sherri A.
凝胶迁移率测定用于确定天然产物贾多霉素家族的一些成员充当DNA切割剂。此外，人们发现，微妙的结构变化产生的通过使用靶向生物合成导致显着的影响，这些糖基化聚酮衍生的天然产物的DNA损伤性能。
Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found that subtle structural changes generated through the use of precursor-directed biosynthesis lead to marked effects on the DNA-damaging properties of these glycosylated polyketide-derived natural products.