Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro.
Endotoxin in vivo impairs endothelium-dependent relaxation of canine arteries in vitro.
复制标题
体内内毒素会损害体外犬动脉的内皮依赖性松弛。
DOI：
10.1164/ajrccm/142.6_pt_1.1263
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Schumacker,PT
中科院分区：
文献类型：
--
作者：
Wylam,ME;Samsel,RW;Umans,JG;Mitchell,RW;Leff,AR;Schumacker,PT
我们研究了内毒素施用/n"/" 0对动脉平滑肌反应/n"/来回的影响，测试了内毒素增强肾上腺素能血管收缩并损害内皮依赖性血管舒张的假设。十只杂种狗_被麻醉并机械通气。其中五只接受了埃舍尔/ch/大肠杆菌内毒素的推注输注（5 mg/kg），其余人接受假输注。 4至5小时后，将麻醉犬迅速放血，并切除股动脉、肾动脉和肠系膜上动脉。动脉环
We studied the effect of endotoxin administration/n"/" 0 on arterial smooth muscle responses/n"/fro, testing the hypotheses that endotoxin augments adrenergic vasoconstriction and Impairs endothellum-dependent vascular relaxation. Ten mongrel dogs _re anesthetized and mechanically ventilated. Five received a bolus Infusion of Escher/ch/a coli endotoxin (5 mg/kg), and the remainder received a sham Infusion. After 4 to 5 h, the anesthetized dogs _re rapidly exsangUinated, and femoral, renal, and superior mesenteric arteries _re removed. Artarlal rings