Altered baseline brain activity in type 2 diabetes: A resting-state fMRI study
Altered baseline brain activity in type 2 diabetes: A resting-state fMRI study
复制标题
2 型糖尿病患者基线大脑活动的改变：一项静息态功能磁共振成像研究
DOI：
10.1016/j.psyneuen.2013.05.012
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发表时间：
2013-11-01
影响因子：
3.7
通讯作者：
Yuan, Yang
中科院分区：
文献类型：
--
作者：
Xia, Wenqing;Wang, Shaohua;Yuan, Yang
目的：本研究旨在通过静息态功能磁共振成像（rs-fMRI）研究2型糖尿病（T2 DM）患者是否存在基线脑活动改变，以及颞中回（MTG）神经活动异常是否与认知功能相关。使用rs-fMRI将T2 DM患者（n = 28）与年龄、性别和教育程度匹配的非糖尿病对照组（n = 29）进行比较。结果：与正常对照组相比，T2 DM患者双侧颞中回、左侧梭状回、左侧枕中回、右侧枕下回的低频波动幅度（ALFF）显著降低;双侧小脑后叶和右侧小脑顶的ALFF值均增加。患者组MTG的ALFF值与HbA 1c（r =-0.451，p = 0.016）和连线测验B评分（r =-0.420，p = 0.026）呈负相关。C肽水平与胰岛β细胞功能呈正相关（r = 0.429，p = 0.023; r = 0.453，p = 0.016）。目前的研究证实，T2 DM患者在许多脑区改变了ALFF，这与神经认知表现差有关，持续高血糖状态和β细胞功能受损的严重程度。MTG的ALFF障碍可能在T2 DM相关的认知功能下降中起重要作用，并可作为未来临床诊断的参考。(C)2013爱思唯尔有限公司保留所有权利。
Purpose: This study aims to investigate whether altered baseline brain activity exists in type 2 diabetes mellitus (T2DM) patients using resting-state functional magnetic resonance imaging (rs-fMRI) and whether abnormal neural activity in the middle temporal gyrus (MTG) is correlated with cognitive function.Methods: T2DM patients (n = 28) were compared with nondiabetic age-, sex-, and education-matched control subjects (n = 29) using rs-fMRI. We computed the amplitude of low-frequency fluctuations (ALFF) of fMRI signals to measure spontaneous neuronal activity and detect the relationship between rs-fMRI information and clinical data.Results: Compared with healthy controls, T2DM patients had significantly decreased ALFF values in the bilateral middle temporal gyrus, left fusiform gyrus, left middle occipital gyrus, right inferior occipital gyrus; and increased ALFF values in both the bilateral cerebellum posterior lobe and right cerebellum culmen. Moreover, we found an inverse correlation between the ALFF values in the MTG and both the HbA1c (r = -0.451, p = 0.016) and the score of Trail Making Test-B (r = -0.420, p = 0.026) in the patient group. On the other hand, C-peptide level and pancreatic beta-cell function had a positive correlation (r = 0.429, p = 0.023; r = 0.453, p = 0.016, respectively) with the ALFF value in the middle temporal gyrus.Conclusion: The present study confirms that T2DM patients have altered ALFF in many brain regions, which is associated with poor neurocognitive performances, severity of consistent hyperglycemic state and impaired beta-cell function. ALFF disturbance in MTG may play a central role in cognitive decline associated with T2DM and serve as reference for future clinical diagnosis. (C) 2013 Elsevier Ltd. All rights reserved.