SPINAL AND MEDULLARY LAMINA-I PROJECTION TO NUCLEUS SUBMEDIUS IN MEDIAL THALAMUS - A POSSIBLE PAIN CENTER
SPINAL AND MEDULLARY LAMINA-I PROJECTION TO NUCLEUS SUBMEDIUS IN MEDIAL THALAMUS - A POSSIBLE PAIN CENTER
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DOI：
10.1152/jn.1981.45.3.443
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
BURTON, H
中科院分区：
文献类型：
--
作者：
CRAIG, AD;BURTON, H
1.用顺行辣根过氧化物酶（HRP）和放射自显影技术获得的结果显示，在猫内侧丘脑的背侧部的中央下核（Sm）的脊髓和三叉神经的密集和紧凑的投影。观察到一个同源的投影在两个案件中的猴子和在三个案件中的大鼠与顺行HRP法。2.投影到Sm在地形组织rostrocaudally，三叉神经终端位于尾部和脊髓终端rostrally。Sm（ca. 1 mm）大于脊髓野（约1 mm）。0.8 mm）。同侧三叉神经有相当大的投射，而到Sm的脊髓投射最少。3.逆行标记的细胞进行了分析的情况下，与小注射HRP在内侧丘脑的猫。结果表明，在顺行实验中确定的Sm的预测产生的椎板I细胞的脊髓和延髓背角，可能不包括椎板V和其他spinothalamic细胞。逆行的结果证实了在顺行实验中所作的地形观测。4.这些结果表明，Sm可能是关键参与特定的伤害性感受。
1. Results obtained with the anterograde horseradish peroxidase (HRP) and autoradiographic techniques have revealed a dense and compact spinal and trigeminal projection to the dorsal portion of the nucleus submedius (Sm) in the medial thalamus of the cat. A homologous projection was observed in two cases in the monkey and in three cases in the rat with the anterograde HRP method. 2. The projection to Sm in topographically organized rostrocaudally, with trigeminal terminations located caudally and spinal terminations rostrally. The rostrocaudal extent of the trigeminal field in Sm (ca. 1 mm) is larger than that of the spinal field (ca. 0.8 mm). There is a considerable ipsilateral trigeminal projection, whereas there is a minimal uncrossed spinal projection to Sm. 3. Retrogradely labeled cells were analyzed in cases with small injections of HRP in medial thalamus in the cat. The results indicate that the projections to Sm identified in the anterograde experiments arise from lamina I cells of the spinal and medullary dorsal horm, probably exclusive of lamina V and other spinothalamic cells. The retrograde results corroborate the topographic observations made in the anterograde experiments. 4. These results suggest that Sm may be critically involved in specific nociception.