A Gene-Brain-Cognition Pathway: Prefrontal Activity Mediates the Effect of COMT on Cognitive Control and IQ
A Gene-Brain-Cognition Pathway: Prefrontal Activity Mediates the Effect of COMT on Cognitive Control and IQ
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DOI：
10.1093/cercor/bhs035
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发表时间：
2013-03-01
期刊：
影响因子：
3.7
通讯作者：
Gray, Jeremy R.
中科院分区：
文献类型：
--
作者：
Green, Adam E.;Kraemer, David J. M.;Gray, Jeremy R.
认知神经遗传学研究的一个核心论点是，基因对认知能力的影响是由特定的神经功能介导的，然而，证明神经介导作用却很困难。到目前为止，基因变异和大脑功能之间的成对关系产生了各种各样的结果。这种异质性表明，多重中介模型方法可能有助于解释涉及多个大脑区域功能的复杂关系。这不仅对于描述健康认知很重要，对于构建疾病相关基因效应在精神疾病中传递到紊乱的认知表型的复杂神经通路模型也很重要。在此，我们对160名进行了基因分型的功能性磁共振成像参与者使用了多重中介模型，以测试一条基因 - 大脑 - 认知通路，即4个前额叶大脑区域的活动介导儿茶酚 - O - 甲基转移酶（COMT）基因对认知控制和智商的影响。研究结果为基因 - 大脑 - 认知介导作用提供了证据，并有助于描绘基因表达对智力有贡献的一条通路。
A core thesis of cognitive neurogenetic research is that genetic effects on cognitive ability are mediated by specific neural functions, however, demonstrating neural mediation has proved elusive. Pairwise relationships between genetic variation and brain function have yielded heterogeneous findings to date. This heterogeneity indicates that a multiple mediator modeling approach may be useful to account for complex relationships involving function at multiple brain regions. This is relevant not only for characterizing healthy cognition but for modeling the complex neural pathways by which disease-related genetic effects are transmitted to disordered cognitive phenotypes in psychiatric illness. Here, in 160 genotyped functional magnetic resonance imaging participants, we used a multiple mediator model to test a gene-brain-cognition pathway by which activity in 4 prefrontal brain regions mediates the effects of catechol-O-methyltransferase ( COMT) gene on cognitive control and IQ. Results provide evidence for gene-brain-cognition mediation and help delineate a pathway by which gene expression contributes to intelligence.