Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation
Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation
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DOI：
10.1038/ncomms1997
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发表时间：
2012-08-01
影响因子：
16.6
通讯作者：
Mansuy, Isabelle M.
中科院分区：
文献类型：
--
作者：
Graeff, Johannes;Woldemichael, Bisrat T.;Mansuy, Isabelle M.
记忆的巩固需要海马体（对记忆形成很重要的大脑区域）和皮层（负责记忆储存的区域）之间及时控制相互作用。在这里，我们表明，记忆巩固与组蛋白的特定表观遗传修饰有关，组蛋白在这些大脑区域具有独特的动态。而在海马中，组蛋白翻译后修饰（PTM）在学习后被迅速和短暂地激活，在皮层中，它们被延迟诱导，但随着时间的推移而持续。当这些组蛋白PTM通过转基因干预或强化训练在体内增加时，它们促进记忆巩固。相反，当它们被阻断时，记忆巩固就会受损。这些组蛋白PTM进一步与立即早期基因zif268的表达相关，zif268是一种有利于记忆巩固的转录因子。这些发现揭示了组蛋白标记在记忆巩固过程中的时空动态，并证明了它们固有的“记忆”属性。
Memory consolidation requires a timely controlled interplay between the hippocampus, a brain region important for memory formation, and the cortex, a region recruited for memory storage. Here we show that memory consolidation is associated with specific epigenetic modifications on histone proteins that have a distinct dynamic in these brain areas. While in the hippocampus, histone post-translational modifications (PTMs) are rapidly and transiently activated after learning, in the cortex they are induced with delay but persist over time. When these histone PTMs are increased in vivo by transgenic intervention or intense training, they facilitate memory consolidation. Conversely, when they are pharmacologically blocked, memory consolidation is impaired. These histone PTMs are further associated with the expression of the immediate early gene zif268, a transcription factor that favours memory consolidation. These findings reveal the spatiotemporal dynamics of histone marks during memory consolidation, and demonstrate their inherent 'mnemonic' property.