Specificity of mixed affective states: clinical comparison of dysphoric mania and agitated depression.
Specificity of mixed affective states: clinical comparison of dysphoric mania and agitated depression.
复制标题
混合情感状态的特异性：烦躁躁狂和激越抑郁的临床比较。
DOI：
10.1016/0165-0327(93)90036-j
复制
发表时间：
1993
影响因子：
6.6
通讯作者：
Stokes,PE
中科院分区：
文献类型：
--
作者：
Swann,AC;Secunda,SK;Katz,MM;Croughan,J;Bowden,CL;Koslow,SH;Berman,N;Stokes,PE
为了研究混合情感状态的临床特异性，我们比较了混合型躁狂（烦躁型）与激动型抑郁患者的临床特征。受试者是在NIMH临床研究分支合作研究抑郁症的心理生物学，生物学研究的住院患者。在为期15天的安慰剂洗脱期内获得抑郁和躁狂症状的行为和症状评级。将激动型抑郁症患者与伴有或不伴有显著抑郁症状的急性躁狂发作患者进行比较。躁狂评分明确区分激动抑郁混合躁狂患者。关于抑郁症和一般精神病理学，混合躁狂症有更严重的躁动，敌意和认知障碍，不激动抑郁症患者。抑郁情绪和焦虑在两组之间没有显著差异。护士对抑郁和焦虑的评分，基于病房的行为，是类似的混合躁狂症和激动抑郁症患者，而医生访谈评定抑郁和焦虑情绪较高的激动抑郁症患者。这些数据支持在混合型躁狂症患者中存在叠加的抑郁和躁狂综合征。
To investigate the clinical specificity of mixed affective states, we compared clinical characteristics of mixed (dysphoric) manics to those of agitated depressed patients. The subjects were inpatients studied in the NIMH Clinical Research Branch Collaborative Study on the Psychobiology of Depression, Biological Studies. Behavior and symptom ratings for depressive and manic symptoms were obtained during a 15-day placebo washout period. Patients with agitated depression were compared to those in acute manic episodes with and without prominent depressive symptoms. Mania ratings clearly distinguished agitated depressed from mixed manic patients. Concerning depression and general psychopathology, mixed manics had more severe agitation, hostility and cognitive impairment that did agitated depressed patients. Depressed mood and anxiety did not differ significantly between the two groups. Nurse ratings for depression and anxiety, based on ward behavior, were similar for mixed manics and agitated depressed patients, while physician-interview rated depression and anxiety were higher in agitated depressed patients. These data support the existence of superimposed depressive and manic syndromes in mixed manics.