Persistent Joint Pain Following Arthropod Virus Infections.
Persistent Joint Pain Following Arthropod Virus Infections.
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DOI：
10.1007/s11926-021-00987-y
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发表时间：
2021-04-13
影响因子：
5
通讯作者：
Chang A
中科院分区：
文献类型：
--
作者：
Suchowiecki K;Reid SP;Simon GL;Firestein GS;Chang A
持续性关节疼痛是节肢动物传播的病毒感染的常见表现，可导致长期残疾。我们回顾了致关节炎甲病毒感染的流行病学、病理生理学、诊断和治疗。甲病毒疫情在全球重新出现，导致病毒引起的关节痛和关节炎增加。甲病毒，包括基孔肯雅病毒、奥尼永尼永病毒、辛德比斯病毒、巴尔马森林病毒、罗斯河病毒和马亚罗病毒，与急性和/或慢性风湿症状有关。 Mxra8 被鉴定为甲病毒复制途径中的病毒进入受体，为治疗和预防创造了机会。最近的证据表明，在慢性基孔肯雅热感染期间，病毒不会持续存在于滑液中，这表明可以安全地给予免疫调节剂。甲病毒感染后持续性关节疼痛的病因仍知之甚少。新的诊断工具和循证治疗可以显着改善发病率和长期残疾。
Persistent joint pain is a common manifestation of arthropod-borne viral infections and can cause long-term disability. We review the epidemiology, pathophysiology, diagnosis, and management of arthritogenic alphavirus infection. The global re-emergence of alphaviral outbreaks has led to an increase in virus-induced arthralgia and arthritis. Alphaviruses, including Chikungunya, O’nyong’nyong, Sindbis, Barmah Forest, Ross River, and Mayaro viruses, are associated with acute and/or chronic rheumatic symptoms. Identification of Mxra8 as a viral entry receptor in the alphaviral replication pathway creates opportunities for treatment and prevention. Recent evidence suggesting virus does not persist in synovial fluid during chronic chikungunya infection indicates that immunomodulators may be given safely. The etiology of persistent joint pain after alphavirus infection is still poorly understood. New diagnostic tools along and evidence-based treatment could significantly improve morbidity and long-term disability.
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影响因子：
7.3
作者：
Broeckel, Rebecca M.;Haese, Nicole;Streblow, Daniel N.
通讯作者：
Streblow, Daniel N.
影响因子：
5
作者：
Camini, Fernanda Caetano;da Silva Caetano, Camila Carla;de Brito Magalhaes, Cintia Lopes
通讯作者：
de Brito Magalhaes, Cintia Lopes
影响因子：
64.5
作者：
Basore, Katherine;Kim, Arthur S.;Fremont, Daved H.
通讯作者：
Fremont, Daved H.
DOI：
10.1590/0001-3765201620150685
发表时间：
2016-09-01
期刊：
Anais da Academia Brasileira de Ciências
影响因子：
--
作者：
CAVALHEIRO, MARIANA G.;COSTA, LEANDRO SILVA DA;POIAN, ANDREA T. DA
通讯作者：
POIAN, ANDREA T. DA
影响因子：
11.8
作者：
Bessaud, Mael;Peyrefitte, Christophe N.;Grandadam, Marc
通讯作者：
Grandadam, Marc