Magnetic source imaging (MSI) in children with neocortical epilepsy: Surgical outcome association with 3D post-resection analysis
Magnetic source imaging (MSI) in children with neocortical epilepsy: Surgical outcome association with 3D post-resection analysis
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DOI：
10.1016/j.eplepsyres.2013.04.004
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发表时间：
2013-09-01
影响因子：
2.2
通讯作者：
Knowlton, Robert
中科院分区：
文献类型：
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作者：
Kim, Hyunmi;Kankirawatana, Pongkiat;Knowlton, Robert
目标：探讨磁源成像（MSI）的有效性，定位癫痫发作区使用三维分析的术前MSI源成像cocorticated后切除MRI后neocorticityepilepsy surgery.Methods：22例儿童谁有MSI和癫痫手术进行了研究（中位年龄= 11岁，1岁2个月至22岁）。只有7例（31.8%）在术前常规脑MRI上有局限性病变。16例（72.7%）进行了颅内脑电图监测。平均术后随访4.7年（1年3个月-8年2个月）。15例患者（68%）无并发症。将MEG尖峰偶极子源叠加到术后MRI上。结果：电偶极子簇的数目和电偶极子在切除体积中的比例与无癫痫发作结局无关（p>0.05）。在7例MRI病变中，其中6例在切除边缘内偶极子>= 70%，而1例在切除边缘内偶极子>= 70%，
Objective: To investigate the validity of magnetic source imaging (MSI) to localize seizure-onset zone using 3D analysis of pre-operative MSI source imaging coregistered to post-resection MRI following neocortical epilepsy surgery.Methods: Twenty-two children who had MSI and epilepsy surgery were studied (median age = 11 years, 1 year 2 months-22 years). Only seven (31.8%) had localized lesions on pre-operative conventional brain MRIs. Sixteen (72.7%) underwent intracranial EEG monitoring. Mean postoperative follow-up was 4.7 years (1 year 3 months-8 years 2 months). Fifteen patients (68%) were seizure-free. MEG spike dipole sources were superimposed onto post-operative MRIs. The number and proportion of spike dipoles within resection volume were calculated and compared between seizure free and non-free groups.Results: Both number of dipole clusters and proportion of dipoles in resection volume were not associated with seizure-free outcome (p>0.05). In seven cases with MRI lesions, six of these with a >= 70% dipoles within the resection margin were seizure-free, while one with the proportion