Antihepatotoxic Principles of Artemisia capillaris Buds1.
Antihepatotoxic Principles of Artemisia capillaris Buds1.
复制标题
茵陈蒿芽的抗肝毒原理1．
作者：
Y. Kiso;S. Ogasawara;K. Hirota;N. Watanabe;Y. Oshima;C. Konno;H. Hikino
由于生药“inchinko”的提取物，即茵陈的芽，通过体内和体外四氯化碳诱导的肝损伤显示出显著的抗肝毒性活性，因此通过监测活性将提取物分级以产生许多黄酮类化合物和香豆素（6，7-二甲基七叶酮）。这些成分的抗肝毒性作用进行了测定体外测定方法使用四氯化碳和半乳糖胺诱导的细胞毒性在原代培养的大鼠肝细胞。一些类似物的dimethylescuaoke也进行了测定的肝脏保护活性。无论是抗肝毒性活性和二甲基escuoke含量在这种植物被发现有显着的变化与收获日期，这被认为是一个显着的变化的抗肝毒性活性在商业上可获得的制剂，这种原料药的原因。
Since an extract of the crude drug "inchinko", the buds of ARTEMISIA CAPILLARIS, showed significant antihepatotoxic activity by means of carbon tetrachloride-induced liver lesion IN VIVO and IN VITRO, the extract was fractionated by monitoring the activity to yield a number of flavonoids and a coumarin (6,7-dimethylesculetin). Antihepatotoxic effects of these constituents were determined by IN VITRO assay methods using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Some analogues of dimethylesculetin were also assayed for liver-protective activity. Both the antihepatotoxic activity and the dimethylesculetin content in this plant were found to vary markedly with the date of harvesting, which was assumed to be a reason for remarkable variations of the antihepatotoxic activity in commercially available preparations of this crude drug.