A muscle stem cell for every muscle: variability of satellite cell biology among different muscle groups.
A muscle stem cell for every muscle: variability of satellite cell biology among different muscle groups.
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DOI：
10.3389/fnagi.2015.00190
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发表时间：
2015
影响因子：
4.8
通讯作者：
Pavlath GK
中科院分区：
文献类型：
--
作者：
Randolph ME;Pavlath GK
人体大约有640块骨骼肌。尽管所有这些肌肉都是由横纹肌组织组成的，但这些肌肉及其相关肌肉干细胞群的生物学是相当多样化的。骨骼肌受到各种肌营养不良症（MD）的不同影响，使得某些基因突变仅在肌肉的一个子集中特异性地改变肌肉功能。此外，有缺陷的肌肉干细胞与一些MD的病理学有关。肌肉干细胞的生物学特性取决于与它们相关的肌肉。在这里，我们回顾了八个不同肌肉群的骨骼肌干细胞群的生物学。了解骨骼肌及其驻留干细胞的生物学变异可以为某些肌肉对肌病易感性的潜在机制提供有价值的见解。
The human body contains approximately 640 individual skeletal muscles. Despite the fact that all of these muscles are composed of striated muscle tissue, the biology of these muscles and their associated muscle stem cell populations are quite diverse. Skeletal muscles are affected differentially by various muscular dystrophies (MDs), such that certain genetic mutations specifically alter muscle function in only a subset of muscles. Additionally, defective muscle stem cells have been implicated in the pathology of some MDs. The biology of muscle stem cells varies depending on the muscles with which they are associated. Here we review the biology of skeletal muscle stem cell populations of eight different muscle groups. Understanding the biological variation of skeletal muscles and their resident stem cells could provide valuable insight into mechanisms underlying the susceptibility of certain muscles to myopathic disease.